NP_001444.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
56,789 Da
NCBI Official Full Name
forkhead box protein C1
NCBI Official Synonym Full Names
forkhead box C1
NCBI Official Synonym Symbols
ARA; IGDA; IHG1; FKHL7; IRID1; RIEG3; FREAC3; FREAC-3 [Similar Products]
NCBI Protein Information
forkhead box protein C1
UniProt Protein Name
Forkhead box protein C1
UniProt Synonym Protein Names
Forkhead-related protein FKHL7; Forkhead-related transcription factor 3; FREAC-3
UniProt Synonym Gene Names
UniProt Entry Name
FOXC1_HUMAN
NCBI Summary for FOXC1
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it has been shown to play a role in the regulation of embryonic and ocular development. Mutations in this gene cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld-Rieger anomaly. [provided by RefSeq, Jul 2008]
UniProt Comments for FOXC1
FOXC1: Binding of FREAC-3 and FREAC-4 to their cognate sites results in bending of the DNA at an angle of 80-90 degrees. Monomer. Expressed in all tissues and cell lines examined.
Protein type: Transcription factor; DNA-binding; Cell development/differentiation; Cell cycle regulation
Chromosomal Location of Human Ortholog: 6p25
Cellular Component: cytoplasm; nuclear heterochromatin; nucleoplasm; nucleus
Molecular Function: DNA bending activity; DNA binding; protein binding; RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding; transcription factor activity; transcription factor binding
Biological Process: artery morphogenesis; blood vessel remodeling; brain development; camera-type eye development; cardiac muscle cell proliferation; cell migration; cell proliferation; collagen fibril organization; embryonic heart tube development; eye development; germ cell migration; glycosaminoglycan metabolic process; heart development; in utero embryonic development; lacrimal gland development; lymph vessel development; mesenchymal cell development; negative regulation of angiogenesis; negative regulation of mitotic cell cycle; neural crest cell development; Notch signaling pathway; odontogenesis of dentine-containing teeth; ossification; ovarian follicle development; paraxial mesoderm formation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of blood vessel size; regulation of organ growth; regulation of transcription, DNA-dependent; skeletal development; somitogenesis; transcription from RNA polymerase II promoter; ureteric bud development; vascular endothelial growth factor receptor signaling pathway; ventricular cardiac muscle morphogenesis
Disease: Axenfeld-rieger Syndrome, Type 3; Iridogoniodysgenesis, Type 1
Research Articles on FOXC1
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Pathways associated with FOXC1 blocking peptide
Diseases associated with FOXC1 blocking peptide
Organs/Tissues associated with FOXC1 blocking peptide
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