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FPN recombinant protein :: Ferroportin (FPN) Recombinant Protein

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Catalog # MBS2012282 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
  0.01 mg  /  $130 +1 FREE 8GB USB
  0.05 mg  /  $225 +1 FREE 8GB USB
  0.1 mg  /  $340 +1 FREE 8GB USB
  0.2 mg  /  $415 +1 FREE 8GB USB
  0.5 mg  /  $800 +1 FREE 8GB USB
  1 mg  /  $1,180 +1 FREE 8GB USB
Product Name

Ferroportin (FPN), Recombinant Protein

Popular Item
Also Known As

Recombinant Ferroportin (FPN)

Matching Pairs
Matching Pairs
Matching Pairs
APC-CY7 Conjugated Antibody: Ferroportin (FPN) (MBS2066084)
Immunogen: Ferroportin (FPN) (MBS2012282)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 2; NC_000002.11 (190425316..190448478, complement). Location: 2q32
OMIM
604653
3D Structure
ModBase 3D Structure for Q9NP59
Host
E Coli
Purity/Purification
> 80%
Form/Format
20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5%Trehalose and Proclin300.
Source
Prokaryotic expression.
Residues
Trp127~Val321 linked with LEHHHHHH
Tags
Two N-terminal Tags, His-tag and GST-tag
Tissue Specificity
Placenta, Spleen.
Subcellular Location
Cell membrane; Multi-pass membrane protein.
Traits
Freeze-dried powder
Predicted isoelectric point
6.0
Predicted Molecular Mass
52.8kDa
Accurate Molecular Mass
52kDa as determined by SDS-PAGE reducing conditions.
Usage
Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
Preparation and Storage
Storage: Avoid repeated freeze/thaw cycles.
Store at 2-8 degree C for one month.
Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed.The loss rate is less than 5% within the expiration date under appropriate storage condition.
Other Notes
Small volumes of FPN recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for FPN recombinant protein
SDS-PAGE, WB, ELISA, IP, CoIP, Purification, Amine Reactive Labeling.
(May be suitable for use in other assays to be determined by the end user.)

Sequence Information of FPN recombinant protein
FPN recombinant protein Sequence Information image
Testing Data of FPN recombinant protein
FPN recombinant protein Testing Data image
NCBI/Uniprot data below describe general gene information for FPN. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
solute carrier family 40 member 1
NCBI Official Synonym Full Names
solute carrier family 40 (iron-regulated transporter), member 1
NCBI Official Symbol
SLC40A1  [Similar Products]
NCBI Official Synonym Symbols
FPN1; HFE4; MTP1; IREG1; MST079; MSTP079; SLC11A3
  [Similar Products]
NCBI Protein Information
solute carrier family 40 member 1; iron regulated gene 1; putative ferroportin 1 variant IIIA; putative ferroportin 1 variant IIIB; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3
UniProt Protein Name
Solute carrier family 40 member 1
UniProt Synonym Protein Names
Ferroportin-1; Iron-regulated transporter 1
UniProt Gene Name
SLC40A1  [Similar Products]
UniProt Synonym Gene Names
FPN1; IREG1; SLC11A3  [Similar Products]
UniProt Entry Name
S40A1_HUMAN
NCBI Summary for FPN
The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4). [provided by RefSeq, Jul 2008]
UniProt Comments for FPN
SLC40A1: May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin). Defects in SLC40A1 are the cause of hemochromatosis type 4 (HFE4). HFE4 is an autosomal dominant iron-loading disorder characterized by early iron accumulation in reticuloendothelial cells and a marked increase in serum ferritin before elevation of the transferrin saturation. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.

Protein type: Transporter; Membrane protein, integral; Membrane protein, multi-pass; Transporter, SLC family

Chromosomal Location of Human Ortholog: 2q32

Cellular Component: multivesicular body; synaptic vesicle; basolateral plasma membrane; integral to plasma membrane; cytoplasm; integral to membrane; plasma membrane; intracellular

Molecular Function: iron ion transmembrane transporter activity; protein binding

Biological Process: anatomical structure morphogenesis; cellular iron ion homeostasis; positive regulation of transcription from RNA polymerase II promoter; transmembrane transport; lymphocyte homeostasis; negative regulation of apoptosis

Disease: Hemochromatosis, Type 4
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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