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FST recombinant protein :: Follistatin Recombinant Protein

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Catalog # MBS553343
Unit / Price
  0.002 mg  /  $145 +1 FREE 8GB USB
  0.01 mg  /  $220 +1 FREE 8GB USB
FST recombinant protein
Product Name

Follistatin (FST), Recombinant Protein

Popular Item
Also Known As

Human Follistatin Recombinant

Product Synonym Names
fst; follicle; follistatin
Matching Pairs
Matching Pairs
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
317
OMIM
136470
3D Structure
ModBase 3D Structure for P19883
Host
HEk293 Cells
Purity/Purification
>95%, as determined by SDS-PAGE and HPLC
Form/Format
Recombinant Human Follistatin was lyophillized at 1mg/ml containing no additives.
Host Note
Optimized DNA sequence encoding Human follistatin mature chain was expressed in Hek293 cells.
Molecular Weight Note
Native human Follistatin, generated by the proteolytic removal of the signal peptide and propeptide, the molecule has a calculated mass of approximately 31 kDa. Recombinant Follistatin is a disulfide- linked monomer protein consisting of 296 amino acid residue subunits, due to glycosylation migrates as an approximately 45 kDa protein under non- reducing and reducing conditions in SDS-PAGE.
Reconstitution
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Biological Activity
The ED(50) was determined by the ability to neutralize Activin A inhibitory effect of mouse MPC-11 and was determined to be 0.1-0.4 ug/ml in the presence of 7.5 ng/ml Activin A.
Edotoxin
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug)
Preparation and Storage
The lyophilized protein is stable for at least 2 years from date of receipt at -20°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2-8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity.

Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of FST recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for FST recombinant protein
NCBI/Uniprot data below describe general gene information for FST. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
Molecular Weight
Native human Follistatin, generated by the proteolytic removal of the signal peptide and propeptide, the molecule has a calculated molecular mass of approximately 31 kDa. Recombinant Follistatin is a disulfide-linked monomer protein consisting of 296 amin
NCBI Official Full Name
follistatin isoform FST317
UniProt Protein Name
Follistatin
UniProt Synonym Protein Names
Activin-binding protein
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
UniProt Entry Name
FST_HUMAN
NCBI Summary for FST
Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. [provided by RefSeq, Jul 2008]
UniProt Comments for FST
FST: Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH). 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 5q11.2

Cellular Component: cytoplasm; extracellular region; nucleus

Molecular Function: heparan sulfate proteoglycan binding; signal transducer activity; protein binding; activin binding

Biological Process: BMP signaling pathway; positive regulation of hair follicle development; negative regulation of activin receptor signaling pathway; negative regulation of cell differentiation; hair follicle morphogenesis; gamete generation; hemopoietic progenitor cell differentiation; negative regulation of transcription from RNA polymerase II promoter; keratinocyte proliferation; skeletal development; pattern specification process; female gonad development; odontogenesis of dentine-containing teeth

Disease: Polycystic Ovary Syndrome 1

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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