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FTL antigen :: Ferritin light chain Antigen

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Catalog # MBS7041641
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FTL antigen
Product Name

Ferritin light chain (FTL), Antigen

Popular Item
Full Product Name

Human Ferritin light chain protein

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
MBS7041641 COA
>95% by SDS-PAGE
Liquid, dissolved in 20mM Tris-HCl, 500mMNaCl, pH 8.0,50% glycerol
Antibody Type
Applications are user defined. Product is developed as raw material and quality control tested in house, data is not provided on the data sheet. The researcher needs to establish and confirm the suitability of the product for their application.

Testing data may be available for this product regarding applications and assays the lab developed, please inquire.
Preparation and Storage
Aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze / thaw cycles.
Other Notes
Small volumes of FTL antigen vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for FTL antigen
Applications Tested/Suitable for FTL antigen
Calibrator, Western Blot (WB)
NCBI/Uniprot data below describe general gene information for FTL. It may not necessarily be applicable to this product.
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
20,020 Da
NCBI Official Full Name
ferritin light chain
NCBI Official Synonym Full Names
ferritin, light polypeptide
NCBI Official Symbol
NCBI Official Synonym Symbols
  [Similar Products]
NCBI Protein Information
ferritin light chain
UniProt Protein Name
Ferritin light chain
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
Ferritin L subunit  [Similar Products]
UniProt Entry Name
NCBI Summary for FTL
This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]
UniProt Comments for FTL
FTL: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. Defects in FTL are the cause of hereditary hyperferritinemia-cataract syndrome (HHCS). It is an autosomal dominant disease characterized by early-onset bilateral cataract. Affected patients have elevated level of circulating ferritin. HHCS is caused by mutations in the iron responsive element (IRE) of the FTL gene. Defects in FTL are the cause of neurodegeneration with brain iron accumulation type 3 (NBIA3); also known as adult-onset basal ganglia disease. It is a movement disorder with heterogeneous presentations starting in the fourth to sixth decade. It is characterized by a variety of neurological signs including parkinsonism, ataxia, corticospinal signs, mild nonprogressive cognitive deficit and episodic psychosis. It is linked with decreased serum ferritin levels. Belongs to the ferritin family.

Protein type: Oxidoreductase

Chromosomal Location of Human Ortholog: 19q13.33

Cellular Component: cytosol; ferritin complex; membrane

Molecular Function: ferric iron binding; identical protein binding; iron ion binding; protein binding

Biological Process: cellular iron ion homeostasis; iron ion homeostasis; iron ion transport

Disease: Hyperferritinemia With Or Without Cataract; L-ferritin Deficiency; Neurodegeneration With Brain Iron Accumulation 3
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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