NP_059108.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
frizzled-3
NCBI Official Synonym Full Names
frizzled class receptor 3
NCBI Official Synonym Symbols
NCBI Protein Information
frizzled-3
UniProt Protein Name
Frizzled-3
UniProt Synonym Gene Names
UniProt Entry Name
FZD3_HUMAN
NCBI Summary for FZD3
This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. The function of this protein is unknown, although it may play a role in mammalian hair follicle development. Alternative splicing results in multiple transcript variants. This gene is a susceptibility locus for schizophrenia. [provided by RefSeq, Dec 2010]
UniProt Comments for FZD3
FZD3: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Belongs to the G-protein coupled receptor Fz/Smo family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: GPCR, Fz/Smo family; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral
Chromosomal Location of Human Ortholog: 8p21
Cellular Component: apical plasma membrane; axon; cell soma; cell surface; cytoplasm; dendrite; filopodium tip; integral to membrane; lateral plasma membrane; plasma membrane; presynaptic active zone
Molecular Function: G-protein coupled receptor activity; PDZ domain binding; protein binding; Wnt receptor activity; Wnt-protein binding
Biological Process: cell proliferation in midbrain; establishment of planar polarity; G-protein coupled receptor protein signaling pathway; hair follicle development; inner ear morphogenesis; negative regulation of mitotic cell cycle, embryonic; neural tube closure; neuron differentiation; neuron migration; positive regulation of neuroblast proliferation; Wnt receptor signaling pathway through beta-catenin
Research Articles on FZD3
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Products associated with FZD3 elisa kit
Pathways associated with FZD3 elisa kit
Diseases associated with FZD3 elisa kit
Organs/Tissues associated with FZD3 elisa kit
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