NP_032087.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
40,473 Da
NCBI Official Full Name
glucose-6-phosphatase
NCBI Official Synonym Full Names
glucose-6-phosphatase, catalytic
NCBI Official Synonym Symbols
G6pt; G6Pase; AW107337; Glc-6-Pase [Similar Products]
NCBI Protein Information
glucose-6-phosphatase
UniProt Protein Name
Glucose-6-phosphatase
UniProt Synonym Gene Names
NCBI Summary for G6pc
The enzyme encoded by this gene is a multisubunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for glucose-6-phosphate, inorganic phosphate, and glucose. This gene is one of three glucose-6-phosphatase catalytic-subunit-encoding genes in mouse. Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I (GSD1). [provided by RefSeq, Sep 2015]
UniProt Comments for G6pc
Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels.
Research Articles on G6pc
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Products associated with G6pc recombinant protein
Pathways associated with G6pc recombinant protein
Diseases associated with G6pc recombinant protein
Organs/Tissues associated with G6pc recombinant protein
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