NP_113600.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
14,044 Da
NCBI Official Full Name
gamma-aminobutyric acid receptor-associated protein-like 1
NCBI Official Synonym Full Names
GABA(A) receptor-associated protein like 1
NCBI Official Synonym Symbols
ATG8; GEC1; APG8L; ATG8B; ATG8L; APG8-LIKE [Similar Products]
NCBI Protein Information
gamma-aminobutyric acid receptor-associated protein-like 1; GEC-1; GABARAPL1-a; early estrogen-regulated protein; glandular epithelial cell protein 1; GABA(A) receptor-associated protein-like 1
UniProt Protein Name
Gamma-aminobutyric acid receptor-associated protein-like 1
UniProt Synonym Protein Names
Early estrogen-regulated protein; GABA(A) receptor-associated protein-like 1; Glandular epithelial cell protein 1; GEC-1
UniProt Synonym Gene Names
UniProt Entry Name
GBRL1_HUMAN
UniProt Comments for GABARAPL1
GABARAPL1: is a ubiquitin-like protein that is a constituent of the ATG8-conjugation system, one of two evolutionarily conserved phosphatidylethanolamine conjugation systems necessary for the formation of the autophagosome. The human ATG8 system includes seven ubiquitin-like light chain proteins (LCPs) that are homologs of yeast LC3: MAP1LC3A, -B, -C, GABARAP, GABARAPL1, -2, and -3. Pro-LCPs are cleaved by ATG4B to expose a C-terminal glycine residue, the cytosolic LCP-I form. The exposed C-terminus is conjugated to the head group amine of phosphatidylethanolamine (PE) through an amide bond by a sequence of ubiquitination-like reactions that involves an E1 (ATG7), an E2 (ATG3), and an E3 (a complex including ATG5, ATG12, and ATG16L). The PE-congugated form (LCP-II) is tightly associated with the autophagosomal membrane. The LCP-II forms can also be delipidated by the ATG4 proteases: most of the LCPs are delipidated and liberated from the membrane before autophagosomes fuse with lysosomes. Increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Belongs to the MAP1 LC3 family. Interacts with GABRG2 and beta-tubulin. Interacts with KOR-1.
Protein type: Microtubule-binding; Ubiquitin-like modifier; Vesicle; Autophagy; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 12p13.2
Cellular Component: dendrite cytoplasm; Golgi apparatus; microtubule; extrinsic to membrane; cytoplasmic vesicle membrane; mitochondrion; endoplasmic reticulum; autophagic vacuole; intracellular; cytosol
Molecular Function: protein binding; Tat protein binding; microtubule binding; GABA receptor binding; beta-tubulin binding
Biological Process: mitochondrion degradation; autophagic vacuole formation
Research Articles on GABARAPL1
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Pathways associated with GABARAPL1 elisa kit
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Organs/Tissues associated with GABARAPL1 elisa kit
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