NP_001074610.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
105,666 Da
NCBI Official Full Name
gamma-aminobutyric acid type B receptor subunit 2
NCBI Official Synonym Full Names
gamma-aminobutyric acid (GABA) B receptor, 2
NCBI Protein Information
gamma-aminobutyric acid type B receptor subunit 2; GABA-BR2; GABA-B-R2; GABA-B receptor 2; G protein-coupled receptor 51; G-protein coupled receptor 51; gamma-aminobutyric acid type B receptor, subunit 2; ortholog of human G protein-coupled receptor 51 GPR51
UniProt Protein Name
Gamma-aminobutyric acid type B receptor subunit 2
UniProt Synonym Protein Names
G-protein coupled receptor 51
UniProt Synonym Gene Names
Gm425; Gpr51; GABA-B receptor 2; GABA-B-R2; GABA-BR2; GABABR2; Gb2 [Similar Products]
UniProt Entry Name
GABR2_MOUSE
UniProt Comments for GABBR2
GABBR2: Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high- voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. Heterodimer of GABA-B-R1 and GABA-B-R2. Neither of which is effective on its own and homodimeric assembly does not seem to happen. Interacts with ATF4 via its C-terminal region. Highly expressed in brain, especially in cerebral cortex, thalamus, hippocampus, frontal, occipital and temporal lobe, occipital pole and cerebellum, followed by corpus callosum, caudate nucleus, spinal cord, amygdala and medulla. Weakly expressed in heart, testis and skeletal muscle. Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 3; Receptor, GPCR
Cellular Component: postsynaptic membrane; neuron projection; membrane; integral to plasma membrane; cytoplasm; integral to membrane; plasma membrane; synapse; cell junction
Molecular Function: G-protein coupled receptor activity; protein binding; signal transducer activity; GABA-B receptor activity
Biological Process: G-protein coupled receptor protein signaling pathway; signal transduction; gamma-aminobutyric acid signaling pathway
Research Articles on GABBR2
Precautions
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Pathways associated with GABBR2 elisa kit
Diseases associated with GABBR2 elisa kit
Organs/Tissues associated with GABBR2 elisa kit
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