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GADD45B recombinant protein

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Catalog # MBS203204
Unit / Price
  0.1 mg  /  $255 +1 FREE 8GB USB
  0.5 mg  /  $535 +1 FREE 8GB USB
SDS-Page
Product Name

GADD45B, Recombinant Protein

Also Known As

GADD45B, 1-160aa, Human, E Coli

Product Synonym Names
Growth arrest and DNA-damage-inducible beta; MYD118; Growth arrest and DNA-damage-inducible beta; GADD45B; Growth arrest and DNA-damage-inducible; beta GADD45 Beta; GADD45BETA; ADD45 beta; growth arrest and DNA-damage-inducible 45 beta; Growth arrest and DNA-damage-inducible protein; myeloid differentiation primary response gene; Myeloid differentiation primary response protein MyD118; Negative growth-regulatory protein MyD118.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
160
Sequence
MTLEELVACD NAAQKMQTVT AAVEELLVAA QRQDRLTVGV YESAKLMNVD PDSVVLCLLA IDEEEEDDIA LQIHFTLIQS FCCDNDINIV RVSGMQRLAQ LLGEPAETQG TTEARDLHCL LVTNPHTDAW KSHGLVEVAS YCEESRGNNQ WVPYISLQER
OMIM
AF090950 mRNA
3D Structure
ModBase 3D Structure for O75293
Host
E Coli
Purity/Purification
> 95% by SDS-PAGE
Form/Format
Liquid. In 20 mM Tris-HCl Buffer (pH 7.5)
Concentration
1 mg/ml (determined by Bradford assay) (lot specific)
Antigen Species
Human
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Other Notes
Small volumes of GADD45B recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
GADD45B recombinant protein
GADD45B is a member of GADD45 family (GADD45alpha, beta, and gamma) that are nuclear proteins to interact with various proteins implicated in stress responses and cell-cycle-related proteins. The function of GADD45 proteins is involved in growth-regulatory mechanisms and apoptosis. GADD45B is necessary for adult neurogenesis, including brain-derived neurotrophic factor and fibroblast growth factor. And therefore, this protein is implicated in affecting synaptic plasticity. Recombinant GADD45B protein was expressed in E Coli and purified by using conventional chromatography techniques.
Product Categories/Family for GADD45B recombinant protein
Applications Tested/Suitable for GADD45B recombinant protein
SDS-PAGE

NCBI/Uniprot data below describe general gene information for GADD45B. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
17.8 kDa (160 aa), confirmed by MALDI-TOF.
NCBI Official Full Name
growth arrest and DNA damage-inducible protein GADD45 beta
NCBI Official Synonym Full Names
growth arrest and DNA damage inducible beta
NCBI Official Symbol
GADD45B  [Similar Products]
NCBI Official Synonym Symbols
MYD118; GADD45BETA
  [Similar Products]
NCBI Protein Information
growth arrest and DNA damage-inducible protein GADD45 beta
UniProt Protein Name
Growth arrest and DNA damage-inducible protein GADD45 beta
UniProt Synonym Protein Names
Myeloid differentiation primary response protein MyD118; Negative growth regulatory protein MyD118
UniProt Gene Name
GADD45B  [Similar Products]
UniProt Synonym Gene Names
MYD118  [Similar Products]
NCBI Summary for GADD45B
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. [provided by RefSeq, Jul 2008]
UniProt Comments for GADD45B
Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.
Product References and Citations for GADD45B recombinant protein
Takekawa M., et al. (1998) Cell 95 (4), 521-30; Zerbini LF., et al. (2004) PNAS 101 (37), 13618-23;

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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