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GAS6 recombinant protein :: Growth Arrest Specific Protein 6 (GAS6) Recombinant Protein

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Catalog # MBS2012078 (2 units are in stock [0.1 mg] for immediate shipment)
Unit / Price
Scan QR to view Datasheet
  0.01 mg  /  $140 +1 FREE 8GB USB
  0.05 mg  /  $265 +1 FREE 8GB USB
  0.1 mg  /  $410 +1 FREE 8GB USB
  0.2 mg  /  $505 +1 FREE 8GB USB
  0.5 mg  /  $980 +1 FREE 8GB USB
  1 mg  /  $1,445 +1 FREE 8GB USB
Product Name

Growth Arrest Specific Protein 6 (GAS6), Recombinant Protein

Popular Item
Full Product Name

Recombinant Growth Arrest Specific Protein 6 (GAS6)

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 16; NC_005115.3 (80701559..80732410, complement). Location: 16q12.5
3D Structure
ModBase 3D Structure for Q63772
Host
E Coli
Purity/Purification
>98%
Concentration
Original Concentration: 200ug/mL (lot specific)
Organism Species
Rattus norvegicus (Rat)
Source
Prokaryotic expression
Residues
Glu100~Gln312
Tags
N-terminal His-Tag
Tissue Specificity
Plasma
Subcellular Location
Secreted
Traits
Freeze-dried powder
Buffer
20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5%Trehalose and Proclin300
Predicted isoelectric point
6.3
Predicted Molecular Mass
24.7kDa
Accurate Molecular Mass
28kDa as determined by SDS-PAGE reducing conditions
Phenomenon explanation
The possible reasons that the actual band size differs from the predicted are as follows:
1. Splice variants: Alternative splicing may create different sized proteins from the same gene.
2. Relative charge: The composition of amino acids may affects the charge of the protein.
3. Post-translational modification: Phosphorylation, glycosylation, methylation etc.
4. Post-translation cleavage: Many proteins are synthesized as pro-proteins, and then cleaved to give the active form.
5. Polymerization of the target protein: Dimerization, multimerization etc.
Usage
Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex
Preparation and Storage
Storage :Avoid repeated freeze/thaw cycles.
Store at 2-8°C for one month.
Aliquot and store at -80°C for 12 months.

Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Other Notes
Small volumes of GAS6 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for GAS6 recombinant protein
Positive Control, Immunogen, SDS-PAGE, WB

(May be suitable for use in other assays to be determined by the end user.)

Sequence Information of GAS6 recombinant protein
GAS6 recombinant protein Sequence Information image
NCBI/Uniprot data below describe general gene information for GAS6. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
NCBI Official Full Name
Growth arrest-specific protein 6
NCBI Official Synonym Full Names
growth arrest specific 6
NCBI Official Symbol
NCBI Protein Information
growth arrest-specific protein 6; GPF; GAS-6; growth-potentiating factor; AXL receptor tyrosine kinase ligand
UniProt Protein Name
Growth arrest-specific protein 6
UniProt Synonym Protein Names
AXL receptor tyrosine kinase ligand; Growth-potentiating factor
UniProt Gene Name
UniProt Synonym Gene Names
GAS-6; GPF  [Similar Products]
UniProt Entry Name
GAS6_RAT
NCBI Summary for GAS6
provides protection of neurons against serum deprivation-induced apoptosis [RGD, Feb 2006]
UniProt Comments for GAS6
GAS6: Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Ligand, receptor tyrosine kinase; Secreted

Cellular Component: extracellular space; cytoplasm; extracellular region; intracellular

Molecular Function: voltage-gated calcium channel activity; growth factor activity; phosphatidylserine binding; caspase inhibitor activity; protein tyrosine kinase activator activity; calcium ion binding; receptor tyrosine kinase binding; receptor agonist activity; molecular adaptor activity; receptor binding

Biological Process: entry of virus into host cell; tissue remodeling; neuron migration; negative regulation of caspase activity; signal transduction; enzyme linked receptor protein signaling pathway; protein amino acid phosphorylation; positive regulation of protein export from nucleus; positive regulation of natural killer cell differentiation; positive regulation of fibroblast proliferation; viral envelope fusion with host membrane; negative regulation of protein import into nucleus, translocation; positive regulation of glomerular filtration; tissue regeneration; negative regulation of interferon-gamma production; regulation of growth; positive regulation of phagocytosis; protein kinase B signaling cascade; negative regulation of interleukin-6 production; positive regulation of TOR signaling pathway; virion attachment, binding of host cell surface receptor; organ regeneration; activation of protein kinase B; negative regulation of transcription factor activity; viral genome replication; negative regulation of tumor necrosis factor production; cellular response to starvation; positive regulation of peptidyl-serine phosphorylation; phagocytosis; cell-substrate adhesion; positive regulation of protein kinase B signaling cascade; peptidyl-serine phosphorylation; positive regulation of protein kinase activity; positive regulation of protein amino acid phosphorylation; negative regulation of transcription, DNA-dependent; positive regulation of cytokine and chemokine mediated signaling pathway; blood coagulation; negative regulation of interleukin-1 secretion; apoptotic cell clearance; negative regulation of apoptosis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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