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GCLC cdna clone

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Catalog # MBS1272408
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  0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
GCLC cdna clone
Product Name

GCLC, cDNA Clone

Popular Item
Full Product Name

GCLC cDNA Clone

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggggctgc tgtcccaggg ctcgccgctg agctgggagg aaaccaagcg ccatgccgac cacgtgcggc ggcacgggat cctccagttc ctgcacatct accacgccgt caaggaccgg cacaaggacg ttctcaagtg gggcgatgag gtggaataca tgttggtatc ttttgatcat gaaaataaaa aagtccggtt ggtcctgtct ggggagaaag ttcttgaaac tctgcaagag aagggggaaa ggacaaaccc aaaccatcct accctttgga gaccagagta tgggagttac atgattgaag ggacaccagg acagccctac ggaggaacaa tgtccgagtt caatacagtt gaggccaaca tgcgaaaacg ccggaaggag gctacttcta tattagaaga aaatcaggct ctttgcacaa taacttcatt tcccagatta ggctgtcctg ggttcacact gcccgaggtc aaacccaacc cagtggaagg aggagcttcc aagtccctct tctttccaga tgaagcaata aacaagcacc ctcgcttcag taccttaaca agaaatatcc gacataggag aggagaaaag gttgtcatca atgtaccaat atttaaggac aagaatacac catctccatt tatagaaaca tttactgagg atgatgaagc ttcaagggct tctaagccgg atcatattta catggatgcc atgggatttg gaatgggcaa ttgctgtctc caggtatag
OMIM
230450
Vector
pENTR223.1
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of GCLC cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for GCLC. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
72,766 Da
NCBI Official Full Name
Homo sapiens glutamate-cysteine ligase, catalytic subunit, mRNA
NCBI Official Synonym Full Names
glutamate-cysteine ligase catalytic subunit
NCBI Official Symbol
NCBI Official Synonym Symbols
GCL; GCS; GLCL; GLCLC
  [Similar Products]
NCBI Protein Information
glutamate--cysteine ligase catalytic subunit
UniProt Protein Name
Glutamate--cysteine ligase catalytic subunit
UniProt Synonym Protein Names
GCS heavy chain; Gamma-ECS; Gamma-glutamylcysteine synthetase
UniProt Gene Name
UniProt Synonym Gene Names
GLCL; GLCLC  [Similar Products]
UniProt Entry Name
GSH1_HUMAN
NCBI Summary for GCLC
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.[provided by RefSeq, Oct 2010]
UniProt Comments for GCLC
GCLC: Defects in GCLC are the cause of hemolytic anemia (HAGGSD). Belongs to the glutamate--cysteine ligase type 3 family.

Protein type: Other Amino Acids Metabolism - glutathione; Ligase; EC 6.3.2.2

Chromosomal Location of Human Ortholog: 6p12

Cellular Component: cytosol; glutamate-cysteine ligase complex

Molecular Function: ADP binding; coenzyme binding; glutamate binding; glutamate-cysteine ligase activity; magnesium ion binding

Biological Process: cell redox homeostasis; cysteine metabolic process; glutamate metabolic process; glutathione biosynthetic process; negative regulation of apoptosis; negative regulation of transcription, DNA-dependent; regulation of blood vessel size; response to heat; response to hormone stimulus; response to oxidative stress; sulfur amino acid metabolic process

Disease: Gamma-glutamylcysteine Synthetase Deficiency, Hemolytic Anemia Due To; Myocardial Infarction, Susceptibility To
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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