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GDF-11 recombinant protein

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Catalog # MBS695875
Unit / Price
  0.005 mg  /  $125 +1 FREE 8GB USB
  0.02 mg  /  $195 +1 FREE 8GB USB
  0.1 mg  /  $640 +1 FREE 8GB USB
  0.5 mg  /  $1,820 +2 FREE 8GB USB
  1 mg  /  $2,980 +3 FREE 8GB USB
GDF-11 recombinant protein
Product Name

GDF-11, Recombinant Protein

Popular Item
Full Product Name

Recombinant Human/Murine/Rat GDF-11

Product Synonym Names
Growth/Differentiation Factor-11, BMP-11
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
NLGLDCDEH SSESRCCRY PLTVDFEAF GWDWIIAPK RYKANYCSG QCEYMFMQK YPHTHLVQQ ANPRGSAGP CCTPTKMSP INMLYFNDK QQIIYGKIP GMVVDRCGC S
OMIM
603936
3D Structure
ModBase 3D Structure for O95390
Host
E Coli
Species Reactivity
Species Reactivity: Human
Cross Reactivity: Mouse
Purity/Purification
> or = 98% as determined by SDS-PAGE Analysis.
Form/Format
Sterile filtered through a 0.2 micron filter. Lyophilized with no additives.
Authenticity
Verified by N-terminal and Mass Spectrometry analyses (when applicable)
Endotoxin
Endotoxin level is<0.1ng/ug of protein (<1EU/ug)
Protein Content
Verified by UV Spectroscopy and/or SDS-PAGE gel.
Biological Activity
Determined by its ability to inhibit induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The ED50 for this effect is 0.08-0.10ug/ml
Cell Type
Neurons
Reconstitution
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0mg/ml. Not: keep pH below 5.0. Do not vortex. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20 degree C to -80 degree C.
Preparation and Storage
At -20 degree C
Other Notes
Small volumes of GDF-11 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
GDF-11 recombinant protein
GDF-11 is a myostatin-homologous protein that acts as an inhibitor of nerve tissue growth. GDF-11 has been shown to suppress neurogenesis through a myostatin-like pathway, which involves arrest of progenitor cell-cycle in the G1 phase. Similarities between myostatin and GDF-11, which are 90% identical in their amino acid sequence, suggests that the regulatory mechanisms responsible for maintaining proper tissue size during neural and muscular development might be the same. Recombinant human GDF-11 is a 25.0 kDa disulfide-linked homodimer containing two 109 amino acid polypeptide chains. It is highly homologous to myostatin/GDF-8 sharing 90% amino-acid sequence identity.
NCBI/Uniprot data below describe general gene information for GDF-11. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Growth/differentiation factor 11
NCBI Official Synonym Full Names
growth differentiation factor 11
NCBI Official Symbol
GDF11  [Similar Products]
NCBI Official Synonym Symbols
BMP11; BMP-11
  [Similar Products]
NCBI Protein Information
growth/differentiation factor 11; GDF-11; bone morphogenetic protein 11
UniProt Protein Name
Growth/differentiation factor 11
UniProt Synonym Protein Names
Bone morphogenetic protein 11; BMP-11
UniProt Gene Name
GDF11  [Similar Products]
UniProt Synonym Gene Names
BMP11; GDF-11; BMP-11  [Similar Products]
UniProt Entry Name
GDF11_HUMAN
NCBI Summary for GDF-11
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice and Xenopus suggest that this protein is involved in mesodermal formation and neurogenesis during embryonic development. [provided by RefSeq, Jul 2008]
UniProt Comments for GDF-11
GDF11: Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern. Belongs to the TGF-beta family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12q13.2

Cellular Component: extracellular space

Molecular Function: growth factor activity; cytokine activity; transforming growth factor beta receptor binding

Biological Process: nervous system development; cell maturation; palate development; regulation of apoptosis; negative regulation of cell proliferation; negative regulation of cell differentiation; camera-type eye morphogenesis; spinal cord anterior/posterior patterning; ureteric bud development; regulation of MAPKKK cascade; pancreas development; mesoderm development; skeletal development; cell development; metanephros development; growth
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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