NP_038554.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
50,942 Da
NCBI Official Full Name
growth/differentiation factor 6
NCBI Official Synonym Full Names
growth differentiation factor 6
NCBI Official Synonym Symbols
NCBI Protein Information
growth/differentiation factor 6; GDF-6; growth differentiation factor 16; growth/differentiation factor 16
UniProt Protein Name
Growth/differentiation factor 6
UniProt Synonym Protein Names
Growth/differentiation factor 16
UniProt Synonym Gene Names
UniProt Entry Name
GDF6_MOUSE
UniProt Comments for GDF-5/CDMP-1
Function: Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map. Required for normal formation of bones and joints in the limbs, skull, and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. May signal through the growth factor receptors subunits BMPR1A, BMPR1B, BMPR2 and ACVR2A. Ref.3 Ref.4 Ref.5
Subunit structure: Homodimer; disulfide-linked
By similarity.
Subcellular location: Secreted
By similarity.
Tissue specificity: Expressed in different subsets of developing joints. Ref.3
Disruption phenotype: Mice lacking Gdf6 display photoreceptor degeneration. Animals exhibit abnormal electroretinograms with up to 66% decreases in the bipolar cell-driven b-wave and 54% decreases in the photoreceptor-mediated a-wave amplitudes, as well as 3 to 27% reduced photopic flicker fusion. Ref.5
Sequence similarities: Belongs to the TGF-beta family.
Research Articles on GDF-5/CDMP-1
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Pathways associated with GDF-5/CDMP-1 active protein
Diseases associated with GDF-5/CDMP-1 active protein
Organs/Tissues associated with GDF-5/CDMP-1 active protein
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