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GDF15 recombinant protein

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Catalog # MBS205834
Unit / Price
  0.1 mg  /  $310 +1 FREE 8GB USB
  0.5 mg  /  $720 +1 FREE 8GB USB
SDS-Page
Product Name

GDF15, Recombinant Protein

Popular Item
Also Known As

GDF15, 189-303aa, Mouse, His tag, E Coli (Denatured)

Product Synonym Names
Growth/differentiation factor 15 precursor; Growth/differentiation factor 15 precursor; MIC-1; NAG-1; SBF
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
303
Sequence
MGSSHHHHHH SSGLVPRGSH MGSSAHAHPR DSCPLGPGRC CHLETVQATL EDLGWSDWVL SPRQLQLSMC VGECPHLYRS ANTHAQIKAR LHGLQPDKVP APCCVPSSYT PVVLMHRTDS GVSLQTYDDL VARGCHCA
3D Structure
ModBase 3D Structure for Q9Z0J7
Host
E Coli
Purity/Purification
> 90% by SDS-PAGE
Form/Format
Liquid. In 20mM Phosphate buffer (pH 8.0) containing 10% glycerol.
Concentration
1.0 mg/ml (determined by Bradford assay) (lot specific)
Antigen Species
Mouse
Tag Information
His-tag
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Other Notes
Small volumes of GDF15 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
GDF15 recombinant protein
Growth/differentiation factor 15, also known as GDF15, is a member of the TGF superfamily. It has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes. They are synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein. Recombinant mouse GDF15 fused to His-tag at N-terminus, was expressed in E Coli.
Product Categories/Family for GDF15 recombinant protein
Applications Tested/Suitable for GDF15 recombinant protein
SDS-PAGE

NCBI/Uniprot data below describe general gene information for GDF15. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
14.9 kDa (138aa)
NCBI Official Full Name
growth/differentiation factor 15 preproprotein
NCBI Official Synonym Full Names
growth differentiation factor 15
NCBI Official Symbol
Gdf15  [Similar Products]
NCBI Official Synonym Symbols
SBF; MIC-1; NAG-1
  [Similar Products]
NCBI Protein Information
growth/differentiation factor 15
UniProt Protein Name
Growth/differentiation factor 15
UniProt Gene Name
Gdf15  [Similar Products]
UniProt Synonym Gene Names
Sbf; GDF-15  [Similar Products]
NCBI Summary for GDF15
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress response program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress. Mice lacking a functional copy of this gene exhibit progressive loss of motor neurons, and more rapid blood clot formation. [provided by RefSeq, Aug 2016]
Product References and Citations for GDF15 recombinant protein
Zimmers TA, Jin X, et al. (2005). Shock. 23 (6):543-8.; Hsiao EC, Koniaris LG, et al. (2000). Mol Cell Biol. 20 (10):3742-51.;

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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