NP_001130002.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
45,267 Da
NCBI Official Full Name
glia-derived nexin isoform c
NCBI Official Synonym Full Names
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
NCBI Official Synonym Symbols
GDN; PI7; PN1; PNI; PI-7; PN-1; GDNPF [Similar Products]
NCBI Protein Information
glia-derived nexin; glial-derived neurite promoting factor; peptidase inhibitor 7; protease nexin I; serpin E2
UniProt Protein Name
Glia-derived nexin
UniProt Synonym Protein Names
Peptidase inhibitor 7; PI-7; Protease nexin 1; PN-1; Protease nexin I; Serpin E2
UniProt Synonym Gene Names
UniProt Entry Name
GDN_HUMAN
NCBI Summary for GDN
This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. Thrombin, urokinase, plasmin and trypsin are among the proteases that this family member can inhibit. This gene is a susceptibility gene for chronic obstructive pulmonary disease and for emphysema. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
UniProt Comments for GDN
SERPINE2: Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin. Belongs to the serpin family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Inhibitor; Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 2q36.1
Cellular Component: extracellular matrix; extracellular space; extrinsic to external side of plasma membrane; extracellular region; cytosol; neuromuscular junction; vesicle
Molecular Function: serine-type endopeptidase inhibitor activity; heparin binding; protein binding; glycosaminoglycan binding; receptor binding
Biological Process: negative regulation of proteolysis; regulation of synaptic transmission, glutamatergic; secretory granule organization and biogenesis; cerebellar granular layer morphogenesis; negative regulation of blood coagulation; mating plug formation; detection of mechanical stimulus involved in sensory perception; regulation of cell migration; negative regulation of cell proliferation; negative regulation of smoothened signaling pathway; negative regulation of cell growth; blood coagulation; negative regulation of protein catabolic process; regulation of timing of cell differentiation; negative regulation of phosphoinositide 3-kinase cascade; secretion by cell; positive regulation of astrocyte differentiation
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Products associated with GDN elisa kit
Pathways associated with GDN elisa kit
Diseases associated with GDN elisa kit
Organs/Tissues associated with GDN elisa kit
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