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GH1 recombinant protein :: Growth Hormone, Recombinant Recombinant Protein

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Catalog # MBS319391
Unit / Price
  0.1 mg  /  $185 +1 FREE 8GB USB
GH1 recombinant protein
Product Name

Growth Hormone, Recombinant (GH1), Recombinant Protein

Also Known As

hGH, Recombinant

Product Synonym Names
hGH, Recombinant; Human Growth Hormone (hGH), Recombinant
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 17; NC_000017.10 (61994563..61996198, complement). Location: 17q24.2
3D Structure
ModBase 3D Structure for P01241
E Coli
Species Reactivity
Growth Hormone, Recombinant
>98% pure (RP-HPLC and SDS-PAGE). Purified by chromatographic techniques. Product is sterile filtered.
Purified, Lyophilized. Reconstitute using sterile deionized water to a concentration >100ug/ml. Further dilutions can be made in other aqueous buffers.
Total protein: 1mg/ml (OD280nm, E0.1% = 0.72). Activity: 3Units/mg (lot specific)
Lyophilized from sodium phosphate buffer containing mannitol
No Preservative
Preparation and Storage
The lyophilized product, though stable for 3 weeks at room temperature, is best stored at -20 degree C. After reconstitution, short term (up to 1 week) store at 2-8 degree C. Long term, add 0.1% HSA or BSA, aliquot and store at -20 degree C. Avoid multiple freeze/thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of GH1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
GH1 recombinant protein
Recombinant Human growth hormone (hGH) is a single, non-glycosylated, polypeptide chain containing 192 amino acids. Molecular weight: 22,260Da. The sequence of the first five N-terminal amino acids was determined to be Met-Phe-Pro-Thr-Ile.
NCBI/Uniprot data below describe general gene information for GH1. It may not necessarily be applicable to this product.
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
24,847 Da[Similar Products]
NCBI Official Full Name
growth hormone
NCBI Official Synonym Full Names
growth hormone 1
NCBI Official Symbol
NCBI Official Synonym Symbols
  [Similar Products]
NCBI Protein Information
somatotropin; pituitary growth hormone
UniProt Protein Name
UniProt Synonym Protein Names
Growth hormone; GH; GH-N; Growth hormone 1; Pituitary growth hormone
Protein Family
UniProt Gene Name
UniProt Entry Name
NCBI Summary for GH1
The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature. [provided by RefSeq]
UniProt Comments for GH1
Function: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.

Subunit structure: Monomer, dimer, trimer, tetramer and pentamer, disulfide-linked or non-covalently associated, in homopolymeric and heteropolymeric combinations. Can also form a complex either with GHBP or with the alpha2-macroglobulin complex.

Subcellular location: Secreted.

Involvement in disease: Defects in GH1 are a cause of growth hormone deficiency isolated type 1A (IGHD1A) [

MIM:262400]; also known as pituitary dwarfism I. IGHD1A is an autosomal recessive deficiency of GH which causes short stature. IGHD1A patients have an absence of GH with severe dwarfism and often develop anti-GH antibodies when given exogenous GH. Ref.19Defects in GH1 are a cause of growth hormone deficiency isolated type 1B (IGHD1B) [

MIM:612781]; also known as dwarfism of Sindh. IGHD1B is an autosomal recessive deficiency of GH which causes short stature. IGHD1B patients have low but detectable levels of GH. Dwarfism is less severe than in IGHD1A and patients usually respond well to exogenous GH.Defects in GH1 are the cause of Kowarski syndrome (KWKS) [

MIM:262650]; also known as pituitary dwarfism VI. Ref.28 Ref.31 Ref.38Defects in GH1 are a cause of growth hormone deficiency isolated type 2 (IGHD2) [

MIM:173100]. IGHD2 is an autosomal dominant deficiency of GH which causes short stature. Clinical severity is variable. Patients have a positive response and immunologic tolerance to growth hormone therapy.

Pharmaceutical use: Available under the names Nutropin or Protropin (Genentech), Norditropin (Novo Nordisk), Genotropin (Pharmacia Upjohn), Humatrope (Eli Lilly) and Saizen or Serostim (Serono). Used for the treatment of growth hormone deficiency and for Turner's syndrome.

Miscellaneous: Circulating GH shows a great heterogeneity due to alternative splicing, differential post-translational modifications of monomeric forms, oligomerization, optional binding to 2 different GH-binding proteins, and potentially proteolytic processing.

Sequence similarities: Belongs to the somatotropin/prolactin family.
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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