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GH1 recombinant protein :: 20kDa Growth Hormone Recombinant Protein

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Catalog # MBS203078
Unit / Price
  0.1 mg  /  $255 +1 FREE 8GB USB
  0.5 mg  /  $535 +1 FREE 8GB USB
SDS-Page
Product Name

20kDa Growth Hormone (GH1), Recombinant Protein

Popular Item
Also Known As

20kDa Growth Hormone, 27-202 aa, Human, E Coli (Bioactivity Validated)

Product Synonym Names
hGH-V; GH2; 20kDa Growth Hormone; Growth hormone 2 isoform 4; HCG1749481; isoform CRA_t; Placental growth hormone 20kDa isoform; Pituitary growth hormone; Growth hormone 1; GH; GH 1; GH N; GH-N; GH1; GHN; Growth hormone; Growth hormone 1 Pituitary growth hormone; Growth hormone 1 variant 1; Growth hormone 1 variant 2; Growth Hormone Normal; Growth Hormone Pituitary; Growth hormone; normal; Growth hormone; pituitary; HG1; hGH N; hGH-N; HGHN; IGHD1B; Pituitary Growth Hormone; RNGHGP; Somatotropin; Somatotropin C; Somatotropin I Precursor
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
217
Sequence
MFPTIPLSRL FDNAMLRAHR LHQLAFDTYQ EFNPQTSLCF SESIPTPSNR EETQQKSNLE LLRISLLLIQ SWLEPVQFLR SVFANSLVYG ASDSNVYDLL KDLEEGIQTL MGRLEDGSPR TGQIFKQTYS KFDTNSHNDD ALLKNYGLLY CFRKDMDKVE TFLRIVQCRS VEGSCGF
OMIM
V00519 mRNA
3D Structure
ModBase 3D Structure for P01241
Host
E Coli
Purity/Purification
> 95% by SDS-PAGE
Form/Format
Liquid. In phosphate buffer saline (pH 7.4) containing 10% glycerol
Concentration
1 mg/ml (determined by BCA assay) (lot specific)
Antigen Species
Human
Endotoxin Level
< 1.0 EU per 1 microgram of protein (determined by LAL method)
Biological Activity
Measured in a cell proliferation assay using Nb2-11 Rat lymphoma cells. The ED50 for this effect is less or equal to 1ng/ml.
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Other Notes
Small volumes of GH1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
GH1 recombinant protein
The 20KDa variant form of human growth hormone (20KDa hGH) presents in extracts from pituitary glands and it differs from the major form of hGH (22K, 191 amino acid) by the deletion of amino acid residues 32-46. The physiological role of 20K hGH remains to be determined partly but it regards the main function as stimulation of somatic and bone growth, as well as an increase in the size and mass of organs and tissues. Recombinant 20KDa human growth hormone was purified by FPLC gel-filtration chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer.
Product Categories/Family for GH1 recombinant protein
Applications Tested/Suitable for GH1 recombinant protein
SDS-PAGE

NCBI/Uniprot data below describe general gene information for GH1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
20 kDa (177 aa), confirmed by MALDI-TOF. [Similar Products]
NCBI Official Full Name
somatotropin isoform 1
NCBI Official Synonym Full Names
growth hormone 1
NCBI Official Symbol
NCBI Official Synonym Symbols
GH; GHN; GH-N; GHB5; hGH-N; IGHD1B
  [Similar Products]
NCBI Protein Information
somatotropin
UniProt Protein Name
Somatotropin
UniProt Synonym Protein Names
Growth hormone; GH; GH-N; Growth hormone 1; Pituitary growth hormone
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
GH; GH-N  [Similar Products]
NCBI Summary for GH1
The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature. [provided by RefSeq, Jul 2008]
UniProt Comments for GH1
Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
Product References and Citations for GH1 recombinant protein
Frigeri, et al (1979) Biochem Biophys Res Commun. 14; 778-82; Adelman, et al (1983) DNA. 2; 183-93; Tsushima, et al (2000) Endocr J. 47; S17-21; Horan, M.,et al (2003) Hum. Mutat. 21 (4), 408-423;

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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