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GH1 recombinant protein :: Growth Hormone (rHuGH) Recombinant Protein

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Catalog # MBS197008
Unit / Price
  0.1 mg  /  $195 +1 FREE 8GB USB
  0.5 mg  /  $280 +1 FREE 8GB USB
  1 mg  /  $395 +1 FREE 8GB USB
GH1 recombinant protein
Product Name

Growth Hormone (rHuGH) (GH1), Recombinant Protein

Popular Item
Also Known As

Recombinant Human Growth Hormone

Product Synonym Names
Recombinant Human Growth Hormone (rHuGH)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 17; NC_000017.10 (61994563..61996198, complement). Location: 17q24.2
OMIM
139250
3D Structure
ModBase 3D Structure for P01241
Host
E Coli
Specificity
Recombinant Human Growth Hormone (rHuGH)
Purity/Purification
Greater than 98% by RP-HPLC, anion-exchange chromatography; reducing and non-reducing SDS-PAGE, silver stain.
Purification: Chromatographic
Form/Format
Sterile filtered, lyophilized.
Dimers/Aggregates
<1% by SDSPAGE
Biological Activity
Fully biologically active compared to the WHO reference standard at 3 Units/mg.
Endotoxin Level
<0.1 ng/ug
Protein Content
Determined spectrophotometrically at 280nm (0.72 ext. coeff), and by RP-HPLC analysis against a calibrated standard.
Solubility
Reconstitute the lyophilized product in sterile water not less than 100 ug/ml.
Stabilizer
None
Preservatives
None
Preparation and Storage
Lyophilized product is stable at room temperature for 3 weeks. Store lyophilized product desiccated at -20 degree C. Upon reconstitution, store at 4 degree C for 2-7 days or aliquot and store at -20 degree C. For long-term storage add either HSA or BSA to 0.1%. Avoid repeated freeze-thaw cycles.
Other Notes
Small volumes of GH1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
GH1 recombinant protein
Recombinant Human Growth Hormone produced in E. coli is a single, nonglycosylated polypeptide chain containing 192 amino acids with a molecular mass of 22,260 daltons. This product has full biological activity.
Product Categories/Family for GH1 recombinant protein
NCBI/Uniprot data below describe general gene information for GH1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
24,847 Da[Similar Products]
NCBI Official Full Name
growth hormone
NCBI Official Synonym Full Names
growth hormone 1
NCBI Official Symbol
NCBI Official Synonym Symbols
GH; GHN; GH-N; hGH-N; IGHD1B
  [Similar Products]
NCBI Protein Information
somatotropin; pituitary growth hormone
UniProt Protein Name
Somatotropin
UniProt Synonym Protein Names
Growth hormone; GH; GH-N; Growth hormone 1; Pituitary growth hormone
Protein Family
UniProt Gene Name
UniProt Entry Name
SOMA_HUMAN
NCBI Summary for GH1
The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature. [provided by RefSeq]
UniProt Comments for GH1
GH: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. Defects in GH1 are a cause of growth hormone deficiency isolated type 1A (IGHD1A); also known as pituitary dwarfism I. IGHD1A is an autosomal recessive deficiency of GH which causes short stature. IGHD1A patients have an absence of GH with severe dwarfism and often develop anti-GH antibodies when given exogenous GH. Defects in GH1 are a cause of growth hormone deficiency isolated type 1B (IGHD1B); also known as dwarfism of Sindh. IGHD1B is an autosomal recessive deficiency of GH which causes short stature. IGHD1B patients have low but detectable levels of GH. Dwarfism is less severe than in IGHD1A and patients usually respond well to exogenous GH. Defects in GH1 are the cause of Kowarski syndrome (KWKS); also known as pituitary dwarfism VI. Defects in GH1 are a cause of growth hormone deficiency isolated type 2 (IGHD2). IGHD2 is an autosomal dominant deficiency of GH which causes short stature. Clinical severity is variable. Patients have a positive response and immunologic tolerance to growth hormone therapy. Belongs to the somatotropin/prolactin family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Hormone; Secreted

Chromosomal Location of Human Ortholog: 17q24.2

Cellular Component: extracellular space; extracellular region

Molecular Function: protein binding; growth hormone receptor binding; growth factor activity; prolactin receptor binding; metal ion binding; hormone activity

Biological Process: positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of MAP kinase activity; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of tyrosine phosphorylation of Stat5 protein; positive regulation of receptor internalization; positive regulation of JAK-STAT cascade; glucose transport; positive regulation of multicellular organism growth; JAK-STAT cascade; response to estradiol stimulus; positive regulation of tyrosine phosphorylation of Stat3 protein

Disease: Isolated Growth Hormone Deficiency, Type Ia; Isolated Growth Hormone Deficiency, Type Ib; Isolated Growth Hormone Deficiency, Type Ii; Kowarski Syndrome
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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