NP_940799.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
32,153 Da
NCBI Official Full Name
growth hormone secretagogue receptor type 1 isoform 1a
NCBI Official Synonym Full Names
growth hormone secretagogue receptor
NCBI Protein Information
growth hormone secretagogue receptor type 1; GHRP; GHS-R; ghrelin receptor; GH-releasing peptide receptor
UniProt Protein Name
Growth hormone secretagogue receptor type 1
UniProt Synonym Protein Names
GH-releasing peptide receptor; GHRP; Ghrelin receptor
UniProt Synonym Gene Names
UniProt Entry Name
GHSR_HUMAN
NCBI Summary for GHSR
This gene encodes a member of the G-protein coupled receptor family. The encoded protein may play a role in energy homeostasis and regulation of body weight. Two identified transcript variants are expressed in several tissues and are evolutionary conserved in fish and swine. One transcript, 1a, excises an intron and encodes the functional protein; this protein is the receptor for the Ghrelin ligand and defines a neuroendocrine pathway for growth hormone release. The second transcript (1b) retains the intron and does not function as a receptor for Ghrelin; however, it may function to attenuate activity of isoform 1a. Mutations in this gene are associated with autosomal idiopathic short stature.[provided by RefSeq, Apr 2010]
UniProt Comments for GHSR
GHSR: Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine). Defects in GHSR may be a cause of idiopathic short stature autosomal (ISSA). Short stature is defined by a subnormal rate of growth. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral
Chromosomal Location of Human Ortholog: 3q26.31
Cellular Component: neuron projection; cell surface; integral to membrane; plasma membrane; lipid raft
Molecular Function: growth hormone secretagogue receptor activity; G-protein coupled receptor activity; peptide hormone binding; growth hormone-releasing hormone receptor activity
Biological Process: positive regulation of insulin-like growth factor receptor signaling pathway; response to food; hormone-mediated signaling; response to hormone stimulus; negative regulation of interleukin-6 biosynthetic process; adult feeding behavior; negative regulation of interleukin-1 beta production; positive regulation of multicellular organism growth; decidualization; negative regulation of insulin secretion; G-protein coupled receptor protein signaling pathway; growth hormone secretion; positive regulation of fatty acid metabolic process; regulation of synaptogenesis; cellular response to insulin stimulus; positive regulation of appetite; actin polymerization and/or depolymerization; negative regulation of inflammatory response; regulation of hindgut contraction; negative regulation of tumor necrosis factor biosynthetic process
Disease: Short Stature, Idiopathic, Autosomal
Research Articles on GHSR
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Products associated with GHSR elisa kit
Pathways associated with GHSR elisa kit
Diseases associated with GHSR elisa kit
Organs/Tissues associated with GHSR elisa kit
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