NP_001186797.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
glutaredoxin-3
NCBI Official Synonym Full Names
glutaredoxin 3
NCBI Official Synonym Symbols
GRX3; GRX4; GLRX4; PICOT; TXNL2; TXNL3 [Similar Products]
NCBI Protein Information
glutaredoxin-3; PKC-interacting cousin of thioredoxin; PKC-theta-interacting protein; PKCq-interacting protein; glutaredoxin 4; thioredoxin-like protein 2
UniProt Protein Name
Glutaredoxin-3
UniProt Synonym Protein Names
PKC-interacting cousin of thioredoxin; PICOT; PKC-theta-interacting protein; PKCq-interacting protein; Thioredoxin-like protein 2
UniProt Synonym Gene Names
UniProt Entry Name
GLRX3_HUMAN
NCBI Summary for GLRX3
This gene encodes a member of the glutaredoxin family. Glutaredoxins are oxidoreductase enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. The encoded protein may also inhibit apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for cancer. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]
UniProt Comments for GLRX3
GLRX3: Critical negative regulator of cardiac hypertrophy and a positive inotropic regulator. May play a role in regulating the function of the thioredoxin system. Does not posses any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity.
Protein type: Oxidoreductase
Chromosomal Location of Human Ortholog: 10q26
Cellular Component: cell cortex; Z disc
Molecular Function: protein binding; electron carrier activity; protein kinase C binding; metal ion binding; protein disulfide oxidoreductase activity; iron-sulfur cluster binding
Biological Process: cell redox homeostasis; regulation of the force of heart contraction
Research Articles on GLRX3
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Products associated with GLRX3 recombinant protein
Diseases associated with GLRX3 recombinant protein
Organs/Tissues associated with GLRX3 recombinant protein
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