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GNalphaI3 elisa kit :: Mouse G Protein Alpha Inhibiting Activity Polypeptide 3 ELISA Kit

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Catalog # MBS086390
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  48-Strip-Wells  /  $470 +1 FREE 8GB USB
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GNalphaI3 elisa kit
Product Name

G Protein Alpha Inhibiting Activity Polypeptide 3 (GNalphaI3), ELISA Kit

Full Product Name

Mouse G Protein Alpha Inhibiting Activity Polypeptide 3 ELISA Kit

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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OMIM
139370
3D Structure
ModBase 3D Structure for P08754
Species Reactivity
Preparation and Storage
Store all reagents at 2-8 degree C
Product Note
Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
Other Notes
Small volumes of GNalphaI3 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for GNalphaI3purchase
MBS086390 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the G Protein Alpha Inhibiting Activity Polypeptide 3 (GNalphaI3) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing GNalphaI3. The ELISA analytical biochemical technique of the MBS086390 kit is based on GNalphaI3 antibody-GNalphaI3 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect GNalphaI3 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, GNalphaI3. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
NCBI/Uniprot data below describe general gene information for GNalphaI3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
40,532 Da
NCBI Official Full Name
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
NCBI Official Synonym Full Names
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
NCBI Official Symbol
GNAI3  [Similar Products]
NCBI Official Synonym Symbols
87U6; ARCND1
  [Similar Products]
NCBI Protein Information
guanine nucleotide-binding protein G(k) subunit alpha; guanine nucleotide-binding protein G(k) subunit alpha; g(i) alpha-3
UniProt Protein Name
Guanine nucleotide-binding protein G(k) subunit alpha
UniProt Synonym Protein Names
G(i) alpha-3
UniProt Gene Name
GNAI3  [Similar Products]
UniProt Entry Name
GNAI3_HUMAN
NCBI Summary for GNalphaI3
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling pathways. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes an alpha subunit and belongs to the G-alpha family. Mutation in this gene, resulting in a gly40-to-arg substitution, is associated with auriculocondylar syndrome, and shown to affect downstream targets in the G protein-coupled endothelin receptor pathway. [provided by RefSeq, Jun 2012]
UniProt Comments for GNalphaI3
G-alpha i3: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(k) is the stimulatory G protein of receptor- regulated K(+) channels. The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division. Defects in GNAI3 are the cause of auriculocondylar syndrome 1 (ARCND1). ARCND1 is an autosomal dominant craniofacial malformation syndrome characterized by variable mandibular anomalies, including mild to severe micrognathia, temporomandibular joint ankylosis, cleft palate, and a characteristic ear malformation that consists of separation of the lobule from the external ear, giving the appearance of a question mark (question-mark ear). Other frequently described features include prominent cheeks, cupped and posteriorly rotated ears, preauricular tags, and microstomia. Belongs to the G-alpha family. G(i/o/t/z) subfamily.

Protein type: G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G((i/o/t/z))

Chromosomal Location of Human Ortholog: 1p13

Cellular Component: Golgi apparatus; centrosome; membrane; lysosomal membrane; cytoplasm; plasma membrane; heterotrimeric G-protein complex; midbody; lipid raft

Molecular Function: GTPase activity; protein domain specific binding; signal transducer activity; GTP binding; metal ion binding; G-protein beta/gamma-subunit binding; GTPase activating protein binding; metabotropic serotonin receptor binding

Biological Process: vesicle fusion; G-protein signaling, coupled to cAMP nucleotide second messenger; platelet activation; synaptic transmission; cell division; transport; metabolic process; negative regulation of adenylate cyclase activity; G-protein signaling, adenylate cyclase inhibiting pathway; blood coagulation; cell cycle

Disease: Auriculocondylar Syndrome 1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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