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GNAS peptide

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Catalog # MBS427301
Unit / Price
  0.1 mg  /  $190 +1 FREE 8GB USB
GNAS peptide
Product Name

GNAS, Peptide

Full Product Name

GNAS Immunizing Peptide

Product Synonym Names
GNAS; GNAS complex locus; AHO; C20orf45; GNAS1; GPSA; GSA; GSP; MGC33735; NESP; PHP1A; PHP1B; POH; dJ309F20.1.1; dJ806M20.3.3; OTTHUMP00000031742; OTTHUMP00000196026; OTTHUMP00000196030; adenylate cyclase-stimulating G alpha protein; guanine nucleotide bi
Product Gene Name
Antibody/Peptide Pairs
GNAS peptide (MBS427301) is used for blocking the activity of GNAS antibody (MBS422378)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
C-QAARSNSD GEKATK
OMIM
102200
Species Reactivity
Human, Mouse, Rat, Cow
Form/Format
100ug of dried peptide
Preparation and Storage
Shipped at ambient temperature, store at -20 degree C
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of GNAS peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for GNAS. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI Related Accession #
Manufactured in an ISO 9001:2015 Certified Laboratory.NP_001070956.1; NP_001070957.1[Other Products]
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
111,025 Da
NCBI Official Full Name
protein GNAS isoform GNASL
NCBI Official Synonym Full Names
GNAS complex locus
NCBI Official Symbol
NCBI Official Synonym Symbols
AHO; GSA; GSP; POH; GPSA; NESP; SCG6; SgVI; GNAS1; C20orf45
  [Similar Products]
NCBI Protein Information
protein ALEX; protein GNAS; protein SCG6 (secretogranin VI)
UniProt Protein Name
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
UniProt Synonym Protein Names
Adenylate cyclase-stimulating G alpha protein
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
GNAS1; GSP  [Similar Products]
UniProt Entry Name
GNAS2_HUMAN
NCBI Summary for GNAS
This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. [provided by RefSeq, Aug 2012]
UniProt Comments for GNAS
G-alpha(s): a guanine nucleotide-binding protein of the G12 class of G-alpha proteins. Agonist binding to Gq-coupled receptors may block Akt activation via the release of active G-alpha(q) subunits that inhibit phosphatidylinositol 3-kinase. Heterotrimeric G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

Protein type: G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G(s); Membrane protein, peripheral; Oncoprotein; Vesicle

Chromosomal Location of Human Ortholog: 20q13.3

Cellular Component: cytosol; membrane

Molecular Function: beta-2 adrenergic receptor binding; corticotropin-releasing hormone receptor 1 binding; D1 dopamine receptor binding; insulin-like growth factor receptor binding; ionotropic glutamate receptor binding; mu-type opioid receptor binding; protein binding

Biological Process: cognition; developmental growth; dopamine receptor, adenylate cyclase activating pathway; G-protein signaling, adenylate cyclase activating pathway; sensory perception of chemical stimulus

Disease: Acth-independent Macronodular Adrenal Hyperplasia; Mccune-albright Syndrome; Osseous Heteroplasia, Progressive; Pituitary Adenoma, Growth Hormone-secreting; Pseudohypoparathyroidism, Type Ia; Pseudohypoparathyroidism, Type Ib; Pseudohypoparathyroidism, Type Ic; Pseudopseudohypoparathyroidism
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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