NP_005078.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
59,920 Da
NCBI Official Full Name
fragile X mental retardation syndrome-related protein 1 isoform a
NCBI Official Synonym Full Names
FMR1 autosomal homolog 1
NCBI Official Synonym Symbols
NCBI Protein Information
fragile X mental retardation syndrome-related protein 1
UniProt Protein Name
Fragile X mental retardation syndrome-related protein 1
UniProt Synonym Gene Names
UniProt Entry Name
FXR1_HUMAN
NCBI Summary for FXR1
The protein encoded by this gene is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for FXR1
FXR1: RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs. Interacts with FMR1 and FXR2. Interacts with TDRD3, and with CYFIP2 but not with CYFIP1. Expressed in all tissues examined including heart, brain, kidney and testis. Belongs to the FMR1 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Translation; RNA-binding
Chromosomal Location of Human Ortholog: 3q28
Cellular Component: axon; costamere; cytoplasm; dendritic spine; membrane; nucleolus; perinuclear region of cytoplasm; polysome
Molecular Function: mRNA 3'-UTR binding; mRNA binding; RNA binding
Biological Process: apoptosis; cell differentiation; muscle development; negative regulation of translation
Research Articles on FXR1
Precautions
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Products associated with FXR1 elisa kit
Pathways associated with FXR1 elisa kit
Diseases associated with FXR1 elisa kit
Organs/Tissues associated with FXR1 elisa kit
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