NP_002072.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
31,931 Da
NCBI Official Full Name
glypican-1
NCBI Official Synonym Full Names
glypican 1
NCBI Official Synonym Symbols
NCBI Protein Information
glypican-1; glypican proteoglycan 1
UniProt Protein Name
Glypican-1
UniProt Entry Name
GPC1_HUMAN
NCBI Summary for GPC1
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. [provided by RefSeq, Jul 2008]
UniProt Comments for GPC1
GPC1: Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination. May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling. Associates (via the heparan sulfate side chains) with fibrillar APP-beta amyloid peptides in primitive and classic amyloid plaques and may be involved in the deposition of these senile plaques in the Alzheimer disease (AD) brain. Misprocessing of GPC1 is found in fibroblasts of patients with Niemann-Pick Type C1 disease. This is due to the defective deaminative degradation of heparan sulfate chains. Belongs to the glypican family.
Protein type: Extracellular matrix; Membrane protein, GPI anchor; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 2q35-q37
Cellular Component: proteinaceous extracellular matrix; lysosomal lumen; extracellular space; integral to plasma membrane; Golgi lumen; plasma membrane; endosome; lipid raft
Molecular Function: heparan sulfate proteoglycan binding; fibroblast growth factor binding; copper ion binding; laminin binding
Biological Process: phototransduction, visible light; axon guidance; heparan sulfate proteoglycan catabolic process; glycosaminoglycan metabolic process; negative regulation of fibroblast growth factor receptor signaling pathway; pathogenesis; Schwann cell differentiation; chondroitin sulfate metabolic process; myelin formation; glycosaminoglycan biosynthetic process; glycosaminoglycan catabolic process; carbohydrate metabolic process; retinoid metabolic process
Research Articles on GPC1
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Products associated with GPC1 elisa kit
Pathways associated with GPC1 elisa kit
Diseases associated with GPC1 elisa kit
Disease Name |
Pubmed Publications |
Disease Models, Animal Antibodies |
>7 publications with GPC1 and Disease Models, Animal |
Nervous System Diseases Antibodies |
>5 publications with GPC1 and Nervous System Diseases |
Inflammation Antibodies |
>3 publications with GPC1 and Inflammation |
Liver Neoplasms Antibodies |
>2 publications with GPC1 and Liver Neoplasms |
Liver Diseases Antibodies |
>2 publications with GPC1 and Liver Diseases |
Carcinoma, Hepatocellular Antibodies |
>2 publications with GPC1 and Carcinoma, Hepatocellular |
Neoplasms, Experimental Antibodies |
>2 publications with GPC1 and Neoplasms, Experimental |
Liver Neoplasms, Experimental Antibodies |
>1 publications with GPC1 and Liver Neoplasms, Experimental |
Cell Transformation, Neoplastic Antibodies |
>1 publications with GPC1 and Cell Transformation, Neoplastic |
Lung Neoplasms Antibodies |
>1 publications with GPC1 and Lung Neoplasms |
Organs/Tissues associated with GPC1 elisa kit
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