NP_003792.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
61,098 Da
NCBI Official Full Name
glycosylphosphatidylinositol anchor attachment 1 protein
NCBI Official Synonym Full Names
glycosylphosphatidylinositol anchor attachment 1
NCBI Official Synonym Symbols
NCBI Protein Information
glycosylphosphatidylinositol anchor attachment 1 protein; GAA1 protein homolog; GPI transamidase subunit; GPI anchor attachment protein 1; GPAA1P anchor attachment protein 1 homolog; glycophosphatidylinositol anchor attachment 1; anchor attachment protein 1 (Gaa1p, yeast) homolog; glycosylphosphatidylinositol anchor attachment protein 1 homolog
UniProt Protein Name
Glycosylphosphatidylinositol anchor attachment 1 protein
UniProt Synonym Protein Names
GAA1 protein homolog; hGAA1
UniProt Synonym Gene Names
UniProt Entry Name
GPAA1_HUMAN
NCBI Summary for GPI
Posttranslational glycosylphosphatidylinositol (GPI) anchor attachment serves as a general mechanism for linking proteins to the cell surface membrane. The protein encoded by this gene presumably functions in GPI anchoring at the GPI transfer step. The mRNA transcript is ubiquitously expressed in both fetal and adult tissues. The anchor attachment protein 1 contains an N-terminal signal sequence, 1 cAMP- and cGMP-dependent protein kinase phosphorylation site, 1 leucine zipper pattern, 2 potential N-glycosylation sites, and 8 putative transmembrane domains. [provided by RefSeq, Jul 2008]
UniProt Comments for GPI
GPAA1: Essential for GPI-anchoring of precursor proteins but not for GPI synthesis. Acts before or during formation of the carbonyl intermediate. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Endoplasmic reticulum; Glycan Metabolism - glycosylphosphatidylinositol (GPI)-anchor biosynthesis
Chromosomal Location of Human Ortholog: 8q24.3
Cellular Component: endoplasmic reticulum membrane; membrane; GPI-anchor transamidase complex
Molecular Function: tubulin binding; protein binding; GPI-anchor transamidase activity
Biological Process: cellular protein metabolic process; attachment of GPI anchor to protein; protein complex assembly; C-terminal protein lipidation; post-translational protein modification; protein retention in ER
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Products associated with GPI elisa kit
Pathways associated with GPI elisa kit
Diseases associated with GPI elisa kit
Organs/Tissues associated with GPI elisa kit
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