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GPT protein :: Alanine Aminotransferase Protein

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Catalog # MBS173089
Unit / Price Please Inquire
GPT protein
Product Name

Alanine Aminotransferase (GPT), Protein

Popular Item
Also Known As

Alanine Aminotransferase (ALT, GPT), Human Liver

Product Synonym Names
Glutamate Pyruvate Transaminase; Alanine Transaminase; serum glutamic-pyruvic transaminase; SGPT; GPT; ALT; ALAT; Alanine Transaminase (ALT, GPT), Human Liver - Lyophilized
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
423
OMIM
138210
3D Structure
ModBase 3D Structure for Q8TD30
Specificity
Liver damage or disease
Purity/Purification
Purified
Form/Format
Lyophilized
Source
Human Liver
EC Number
2.6.1.2
UNSPSC Code
51131907
Unit Definition
One unit will catalyze the transamination of one micromole of L-alanine to alpha-ketoglutarate, forming L-glutamate and pyruvate per minute at 37 degree C and pH 7.8. Measured at 340 nm as one equimolar amount of NAD produced by a coupled reaction.
Specific Activity
>= 10 U/mg protein
Recertification
3 years
Protein
>= 0.5 mg protein/mg (Coomassie)
Contaminants
ALP: <=0.1%, CK: <=0.1%, gGT: <=0.1%, AST/SGOT: <=3%, LDH: <=1%
CAS Number
9000-86-6
Additional Info
Homodimer
Activity
>= 5 U/mg (Dimension Clinical Chemistry System)
Preparation and Storage
At -20 degree C
Other Notes
Small volumes of GPT protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
GPT protein
MyBioSource is the leading producer of Alanine Aminotransferase (ALT, GPT), Human Liver for research and diagnostic use. We are able to custom fill alanine aminotransferase.

Custom preparations, technical support, bulk quantities and aliquoting available.

Human GPT/ALT is an enzyme that catalyzes the reversible transfer of an amino group from alanine to a-ketoglutarate. Human alanine aminotransferase (ALT) is found in serum and in various bodily tissues but is most commonly associated with the liver. Also called serum glutamate pyruvate transaminase (SGPT) or alanine aminotransferase.

Elevated levels of Alanine transaminase (ALT) often suggest the existence of other medical problems such as alcoholism, viral hepatitis, congestive heart failure, liver damage, biliary duct problems, infectious mononucleosis, or myopathy.
NCBI/Uniprot data below describe general gene information for GPT. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
57,903.6 based on the sequence[Similar Products]
NCBI Official Full Name
glutamate pyruvate transaminase
NCBI Official Synonym Full Names
glutamic-pyruvate transaminase (alanine aminotransferase)
NCBI Official Symbol
NCBI Official Synonym Symbols
AAT1; ALT1; GPT1
  [Similar Products]
NCBI Protein Information
alanine aminotransferase 1; GPT 1; glutamic-alanine transaminase 1; glutamic--alanine transaminase 1; glutamic--pyruvic transaminase 1; glutamate pyruvate transaminase 1
UniProt Protein Name
Alanine aminotransferase 2
UniProt Synonym Protein Names
Glutamate pyruvate transaminase 2; GPT 2; Glutamic--alanine transaminase 2; Glutamic--pyruvic transaminase 2
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
AAT2; ALT2; ALT2; GPT 2  [Similar Products]
UniProt Entry Name
ALAT2_HUMAN
NCBI Summary for GPT
This gene encodes cytosolic alanine aminotransaminase 1 (ALT1); also known as glutamate-pyruvate transaminase 1. This enzyme catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate and, therefore, plays a key role in the intermediary metabolism of glucose and amino acids. Serum activity levels of this enzyme are routinely used as a biomarker of liver injury caused by drug toxicity, infection, alcohol, and steatosis. A related gene on chromosome 16 encodes a putative mitochondrial alanine aminotransaminase.[provided by RefSeq, Nov 2009]
UniProt Comments for GPT
GPT2: Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.6.1.2; Transferase; Amino Acid Metabolism - alanine, aspartate and glutamate; Mitochondrial

Chromosomal Location of Human Ortholog: 16q12.1

Cellular Component: mitochondrial matrix

Molecular Function: alanine transaminase activity; pyridoxal phosphate binding

Biological Process: amino acid biosynthetic process; L-alanine metabolic process; 2-oxoglutarate metabolic process; L-alanine catabolic process

Disease: Mental Retardation, Autosomal Recessive 49
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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