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GPX3 cdna clone

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Catalog # MBS1271166
Unit / Price
  0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
GPX3 cdna clone
Product Name

GPX3, cDNA Clone

Popular Item
Also Known As

GPX3 cDNA Clone

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
681
Sequence
atggcccggc tgctgcaggc gtcctgcctg ctttccctgc tcctggccgg cttcgtctcg cagagccggg gacaagagaa gtcgaagatg gactgccatg gtggcataag tggcaccatt tacgagtacg gagccctcac cattgatggg gaggagtaca tccccttcaa gcagtatgct ggcaaatacg tcctctttgt caacgtggcc agctactgag gcctgacggg ccagtacatt gaactgaatg cactacagga agagcttgca ccattcggtc tggtcattct gggctttccc tgcaaccaat ttggaaaaca ggaaccagga gagaactcag agatccttcc taccctcaag tatgtccgac caggtggagg ctttgtccct aatttccagc tctttgagaa aggggatgtc aatggagaga aagagcagaa attctacact ttcctaaaga actcctgtcc tcccacctcg gagctcctgg gtacatctga ccgcctcttc tgggaaccca tgaaggttca cgacatccgc tggaactttg agaagttcct ggtggggcca gatggtatac ccatcatgcg ctggcaccac cggaccacgg tcagcaacgt caagatggac atcctgtcct acatgaggcg gcaggcagcc ctgggggtca agaggaagta a
OMIM
138321
Vector
pENTR223.1
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of GPX3 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for GPX3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
25,552 Da
NCBI Official Full Name
Homo sapiens glutathione peroxidase 3 (plasma), mRNA
NCBI Official Synonym Full Names
glutathione peroxidase 3
NCBI Official Symbol
NCBI Official Synonym Symbols
GPx-P; GSHPx-3; GSHPx-P
  [Similar Products]
NCBI Protein Information
glutathione peroxidase 3
UniProt Protein Name
Glutathione peroxidase 3
UniProt Synonym Protein Names
Extracellular glutathione peroxidase; Plasma glutathione peroxidase; GPx-P; GSHPx-P
UniProt Gene Name
UniProt Synonym Gene Names
GPXP; GPx-3; GSHPx-3; GPx-P; GSHPx-P  [Similar Products]
UniProt Entry Name
GPX3_HUMAN
NCBI Summary for GPX3
The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is secreted, and is abundantly found in plasma. Downregulation of expression of this gene by promoter hypermethylation has been observed in a wide spectrum of human malignancies, including thyroid cancer, hepatocellular carcinoma and chronic myeloid leukemia. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016]
UniProt Comments for GPX3
GPX3: Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. Belongs to the glutathione peroxidase family.

Protein type: Oxidoreductase; Secreted; Secreted, signal peptide; EC 1.11.1.9; Other Amino Acids Metabolism - glutathione; Lipid Metabolism - arachidonic acid

Chromosomal Location of Human Ortholog: 5q33.1

Cellular Component: extracellular region; extracellular space

Molecular Function: glutathione peroxidase activity; protein binding; selenium binding; transcription factor binding

Biological Process: hydrogen peroxide catabolic process; protein homotetramerization; response to lipid hydroperoxide; response to reactive oxygen species
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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