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Grb10 recombinant protein :: Growth factor receptor-bound protein 10 (Grb10) Recombinant Protein

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Catalog # MBS956222
Unit / Price
  0.05 mg (E-Coli)  /  $1,020 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $1,205 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $1,380 +1 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,455 +1 FREE 8GB USB
  0.2 mg (Yeast)  /  $1,465 +1 FREE 8GB USB
  0.5 mg (E-Coli)  /  $1,520 +1 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $1,530 +1 FREE 8GB USB
  0.5 mg (Yeast)  /  $1,655 +2 FREE 8GB USB
  1 mg (E-Coli)  /  $2,165 +2 FREE 8GB USB
  0.5 mg (Baculovirus)  /  $2,185 +2 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $2,190 +2 FREE 8GB USB
  1 mg (Yeast)  /  $2,505 +3 FREE 8GB USB
  1 mg (Baculovirus)  /  $2,870 +3 FREE 8GB USB
Grb10 recombinant protein
Product Name

Growth factor receptor-bound protein 10 (Grb10), Recombinant Protein

Also Known As

Recombinant Rat Growth factor receptor-bound protein 10 (Grb10)

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-599aa, Full length protein
Sequence Length
599
Sequence
MNNDINSSVE SLNSACNMQS DTDTVPLLEN GQSASNQPSA SSSRGQPQAS PRQKMQRSQP VHIQPLRRLQ EEDQQLRTSS LPAIPNPFPE LAGGAPGSPP SVAPSSLPPP PSQPPAKHFP PGFQLAKLTR PGLWTKTTAR FSKRQPKNQC QTDTANAVSR IPTSQMEKLR LRKDVKVFSE DGTSKVVEIL TDMTARDLCQ LLVYKSHCVD DNSWTLVEHH PQLGLERCLE DHEIVVQVES TMPSESKFLF RKNYAKYEFF KNPVNFFPDQ MVTWCQQSNG GQAQLLQNFL NSSSCPEIQG FLQVKEVGRK SWKKLYVCLR RSGLYYSTKG TSKEPRHLQL LADLEESSIF YLIAGKKQYN APNEHGMCIK PNKAKIEMKE LRLLCAEDEQ IRTCWMTAFR LLKYGMLLYQ NYRIPQQRKG LAPPFNAPMR SVSENSLVAM DFSGQIGRVI DNPAEAQSAA LEEGHAWRKR STRMNILSSQ SPLHPSTLNS VIHRTQHWFH GRISREESHR IIKQQGLVDG LFLLRDSQSN PKAFVLTLCH QQKIRNFQIL PCEDDGQTFF TLDDGNTKFS DLIQLVDFYQ LNKGVLPCKL KHHCIRVAL
3D Structure
ModBase 3D Structure for P0CE43
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Rat
Storage Buffer
Tris-based buffer, 50% glycerol
Tag Information
Tag type will be determined during the manufacturing process
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of Grb10 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Grb10 recombinant protein
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner. Alternatively spliced transcript variants encoding different isoforms have been identified.
NCBI/Uniprot data below describe general gene information for Grb10. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
67,882 Da
NCBI Official Full Name
growth factor receptor-bound protein 10 isoform X2
NCBI Official Synonym Full Names
growth factor receptor bound protein 10
NCBI Official Symbol
Grb10  [Similar Products]
NCBI Official Synonym Symbols
RGD1566234
  [Similar Products]
NCBI Protein Information
growth factor receptor-bound protein 10
UniProt Protein Name
Growth factor receptor-bound protein 10
UniProt Synonym Protein Names
GRB10 adapter protein
UniProt Gene Name
Grb10  [Similar Products]
UniProt Comments for Grb10
Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. A similar role in the mediation of ubiquitination has also been suggested with INSR. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2 ().
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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