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GRIK2 cdna clone

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Catalog # MBS1275934
Unit / Price
  0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
GRIK2 cdna clone
Product Name

GRIK2, cDNA Clone

Also Known As

GRIK2 cDNA Clone

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
1062
Sequence
atgaagatta ttttcccgat tctaagtaat ccagtcttca ggcgcaccgt taaactcctg ctctgtttac tgtggattgg atattctcaa ggaaccacac atgtattaag atttggtggt atttttgaat atgtggaatc tggcccaatg ggagctgagg aacttgcatt cagatttgct gtgaacacaa ttaacagaaa cagaacattg ctacccaata ctacccttac ctatgatacc cagaagataa acctttatga tagttttgaa gcatccaaga aagcctgtga tcagctgtct cttggggtgg ctgccatctt cgggccttca cacagctcat cagcaaacgc agtgcagtcc atctgcaatg ctctgggagt tccccacata cagacccgct ggaagcacca ggtgtcagac aacaaagatt ccttctatgt cagtctctac ccagacttct cttcactcag ccgtgccatt ttagacctgg tgcagttttt caagtggaaa accgtcacgg ttgtgtatga tgacagcact ggtctcattc gtttgcaaga gctcatcaaa gctccatcaa ggtataatct tcgactcaaa attcgtcagt tacctgctga tacaaaggat gcaaaaccct tactaaaaga aatgaaaaga ggcaaggagt ttcatgtaat ctttgattgt agccatgaaa tggcagcagg cattttaaaa caggcattag ctatgggaat gatgacagaa tactatcatt atatctttac cactctggac ctctttgctc ttgatgttga gccctaccga tacagtggtg ttaacatgac agggttcaga atattaaata cagaaaatac ccaagtctcc tccatcattg aaaagtggtc gatggaacga ttgcaggcac ctccgaaacc cgattcaggt ttgctggatg gatttatgac gatggagttt cactcttgtt gcccaggctg gagtgcaatg gcgcgatctc acctcactgc aacctctgcc tcctgggttc aagcgattct tctgcctcag cctcccgagt ag
OMIM
138244
Vector
pENTR223.1 or pUC
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of GRIK2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for GRIK2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
77,112 Da
NCBI Official Full Name
Homo sapiens glutamate receptor, ionotropic, kainate 2, mRNA
NCBI Official Synonym Full Names
glutamate ionotropic receptor kainate type subunit 2
NCBI Official Symbol
GRIK2  [Similar Products]
NCBI Official Synonym Symbols
EAA4; GLR6; MRT6; GLUK6; GLUR6; GluK2
  [Similar Products]
NCBI Protein Information
glutamate receptor ionotropic, kainate 2
UniProt Protein Name
Glutamate receptor ionotropic, kainate 2
UniProt Synonym Protein Names
Excitatory amino acid receptor 4; EAA4; Glutamate receptor 6; GluR-6; GluR6
UniProt Gene Name
GRIK2  [Similar Products]
UniProt Synonym Gene Names
GLUR6; GluK2; EAA4; GluR-6; GluR6  [Similar Products]
UniProt Entry Name
GRIK2_HUMAN
NCBI Summary for GRIK2
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. Mutations in this gene have been associated with autosomal recessive mental retardation. [provided by RefSeq, Jul 2008]
UniProt Comments for GRIK2
GluR6: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface expression of NETO2. Defects in GRIK2 are the cause of mental retardation autosomal recessive type 6 (MRT6). It is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. In contrast to syndromic or specific mental retardation which also present with associated physical, neurological and/or psychiatric manifestations, intellectual deficiency is the only primary symptom of non-syndromic mental retardation. MRT6 patients display mild to severe mental retardation and psychomotor development delay in early childhood. Patients do not have neurologic problems, congenital malformations, or facial dysmorphism. Body height, weight, and head circumference are normal. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK2 subfamily. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, calcium; Channel, ligand-gated

Chromosomal Location of Human Ortholog: 6q16.3

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: kainate selective glutamate receptor activity; ligand-gated ion channel activity

Biological Process: glutamate signaling pathway; positive regulation of synaptic transmission; regulation of short-term neuronal synaptic plasticity; regulation of synaptic transmission; synaptic transmission

Disease: Mental Retardation, Autosomal Recessive 6
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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