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GRIK2 elisa kit :: Chicken Glutamate Receptor, Ionotropic, Kainate 2 ELISA Kit

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Catalog # MBS752950
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GRIK2 elisa kit
Product Name

Glutamate Receptor, Ionotropic, Kainate 2 (GRIK2), ELISA Kit

Full Product Name

Chicken Glutamate Receptor, Ionotropic, Kainate 2 ELISA Kit

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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Chromosome Location
Chromosome: 6; NC_000006.11 (101846861..102517958). Location: 6q16.3
OMIM
138244
3D Structure
ModBase 3D Structure for Q13002
Species Reactivity
Preparation and Storage
Store all reagents at 2-8 degree C
Sample Preparation
We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
Product Note
Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
Other Notes
Small volumes of GRIK2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for GRIK2purchase
MBS752950 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Glutamate Receptor, Ionotropic, Kainate 2 (GRIK2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing GRIK2. The ELISA analytical biochemical technique of the MBS752950 kit is based on GRIK2 antibody-GRIK2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect GRIK2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, GRIK2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
Product Categories/Family for GRIK2 elisa kit
NCBI/Uniprot data below describe general gene information for GRIK2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
102,583 Da
NCBI Official Full Name
glutamate receptor ionotropic, kainate 2 isoform 3
NCBI Official Synonym Full Names
glutamate receptor, ionotropic, kainate 2
NCBI Official Symbol
GRIK2  [Similar Products]
NCBI Official Synonym Symbols
EAA4; GLR6; MRT6; GLUK6; GLUR6; GluK2
  [Similar Products]
NCBI Protein Information
glutamate receptor ionotropic, kainate 2; gluR-6; bA487F5.1; glutamate receptor 6; glutamate receptor form A; glutamate receptor form B; glutamate receptor form C; glutamate receptor form D; glutamate receptor form E; excitatory amino acid receptor 4
UniProt Protein Name
Glutamate receptor ionotropic, kainate 2
UniProt Synonym Protein Names
Excitatory amino acid receptor 4; EAA4; Glutamate receptor 6
UniProt Gene Name
GRIK2  [Similar Products]
UniProt Synonym Gene Names
GLUR6; GluK2; EAA4; GluR-6; GluR6  [Similar Products]
UniProt Entry Name
GRIK2_HUMAN
NCBI Summary for GRIK2
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. Mutations in this gene have been associated with autosomal recessive mental retardation. [provided by RefSeq, Jul 2008]
UniProt Comments for GRIK2
GluR6: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface expression of NETO2. Defects in GRIK2 are the cause of mental retardation autosomal recessive type 6 (MRT6). It is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. In contrast to syndromic or specific mental retardation which also present with associated physical, neurological and/or psychiatric manifestations, intellectual deficiency is the only primary symptom of non-syndromic mental retardation. MRT6 patients display mild to severe mental retardation and psychomotor development delay in early childhood. Patients do not have neurologic problems, congenital malformations, or facial dysmorphism. Body height, weight, and head circumference are normal. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK2 subfamily. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, calcium; Channel, ligand-gated

Chromosomal Location of Human Ortholog: 6q16.3

Cellular Component: presynaptic membrane; dendrite cytoplasm; postsynaptic membrane; kainate selective glutamate receptor complex; integral to plasma membrane; postsynaptic density; dendrite; plasma membrane; terminal button; perikaryon; cell junction

Molecular Function: protein homodimerization activity; extracellular-glutamate-gated ion channel activity; kainate selective glutamate receptor activity; ubiquitin conjugating enzyme binding; ubiquitin protein ligase binding; PDZ domain binding

Biological Process: regulation of long-term neuronal synaptic plasticity; regulation of synaptic transmission; synaptic transmission, glutamatergic; behavioral fear response; glutamate signaling pathway; negative regulation of synaptic transmission, glutamatergic; generation of action potential; regulation of short-term neuronal synaptic plasticity; regulation of JNK cascade; receptor clustering; positive regulation of synaptic transmission; cellular calcium ion homeostasis; regulation of inhibitory postsynaptic membrane potential; synaptic transmission; intracellular protein transport; neuron apoptosis; ionotropic glutamate receptor signaling pathway; transport; positive regulation of neuron apoptosis; negative regulation of neuron apoptosis; regulation of excitatory postsynaptic membrane potential

Disease: Mental Retardation, Autosomal Recessive 6
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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