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GRO beta recombinant protein

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Catalog # MBS539428
Unit / Price
  0.025 mg  /  $310 +1 FREE 8GB USB
GRO beta recombinant protein
Product Name

GRO beta, Recombinant Protein

Also Known As

GRO beta protein

Product Synonym Names
GRO2 protein; MGSAbeta protein; MIP-2 protein; Growth Regulated Protein/Melanoma Growth Stimulatory Activity protein; CXCL2 protein
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
3
Sequence
Region of GRO beta protein correspond ing to amino acids VVVASELRCQ CLTTLPRVDF KNIQSLTVTP PGPHCAQTEV IATLKDGHEV CLNPEAPLVQ RIVQKILNKG KAN.
OMIM
139110
Host
Human
Purity/Purification
> 98% pure
Form/Format
Supplied as a lyophilized powder.
Protein Type
Recombinant
Biological Significance
All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant rat GRO-beta/MIP-2 is a 7.9 kDa protein consisting of 73 amino acids including the 'ELR' motif common to the CXC chemokine family that bind to CXCR1 or CXCR2.
Bioactivity
Determined by its ability to chemoattract rat neutrophils using a concentration range of 10.0-100.0 ng/ml.
Endotoxin Levels
Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
Expression System
E Coli
Preparation and Storage
Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of GRO beta recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
GRO beta recombinant protein
Purified recombinant Human GRO beta protein
Applications Tested/Suitable for GRO beta recombinant protein
User optimized
NCBI/Uniprot data below describe general gene information for GRO beta. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
7.8 kDa
NCBI Official Full Name
GRO-beta, partial
NCBI Official Synonym Full Names
chemokine (C-X-C motif) ligand 2
NCBI Official Symbol
CXCL2  [Similar Products]
NCBI Official Synonym Symbols
GRO2; GROb; MIP2; MIP2A; SCYB2; MGSA-b; MIP-2a; CINC-2a
  [Similar Products]
NCBI Protein Information
C-X-C motif chemokine 2
UniProt Protein Name
C-X-C motif chemokine 2
UniProt Synonym Protein Names
Growth-regulated protein beta; Gro-beta
UniProt Gene Name
CXCL2  [Similar Products]
UniProt Synonym Gene Names
GRO2; GROB; MIP2A; SCYB2; Gro-beta; MIP2-alpha; HSF  [Similar Products]
UniProt Entry Name
CXCL2_HUMAN
NCBI Summary for GRO beta
This antimicrobial gene is part of a chemokine superfamily that encodes secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CXC subfamily, is expressed at sites of inflammation and may suppress hematopoietic progenitor cell proliferation. [provided by RefSeq, Sep 2014]
UniProt Comments for GRO beta
CXCL2: Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: extracellular space; extracellular region

Molecular Function: protein binding; chemokine activity; CXCR chemokine receptor binding

Biological Process: G-protein coupled receptor protein signaling pathway; response to molecule of bacterial origin; positive regulation of leukocyte chemotaxis; immune response; response to lipopolysaccharide; inflammatory response; chemotaxis; regulation of cell proliferation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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