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GRO g recombinant protein :: GRO-gamma Recombinant Protein

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Catalog # MBS142019
Unit / Price
  0.002 mg  /  $140 +1 FREE 8GB USB
  0.01 mg  /  $205 +1 FREE 8GB USB
  1 mg  /  $2,665 +3 FREE 8GB USB
GRO g recombinant protein
Product Name

GRO-gamma (GRO g), Recombinant Protein

Also Known As

Recombinant Human GRO-gamma (CXCL3)

Product Synonym Names
GRO g Human; GRO-Gamma Human Recombinant (CXCL3); Macrophage inflammatory protein 2-beta; MIP2-beta; CXCL3; Growth-regulated protein gamma; GRO-gamma; GRO-gamma(1-73); GRO3; GROg; MIP2B; SCYB3; MIP-2b; CINC-2b; MGSA gamma
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
107
Sequence
The sequence of the first five N-terminal amino acids was determined and was found to be Ala-Ser-Va l-Val-Thr
OMIM
139111
3D Structure
ModBase 3D Structure for P19876
Host
E Coli
Purity/Purification
Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Form/Format
The protein was lyophilized with no additives.
Sterile Filtered White lyophilized (freeze-dried) powder.
Solubility
It is recommended to reconstitute the lyophilized CXCL3 in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Biological Activity
The Biological activity is calculated by its ability to chemoattract CXCR2 transfected 293 cells using 10-100ng/ml corresponding to a Specific Activity of 10,000-100,000IU/mg.
Preparation and Storage
Lyophilized GRO-gamma although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution CXCL3 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Other Notes
Small volumes of GRO g recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
GRO g recombinant protein
Description: GRO-Gamma Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 73 amino acids and having a molecular mass of 7902 Dalton. The CXCL3 is purified by proprietary chromatographic techniques.

Introduction: Chemokine (C-X-C motif) ligand 3 (CXCL3) is a small cytokine belonging to the CXC chemokine family that is also known as GRO3 oncogene (GRO3), GRO protein gamma (GROg) and macrophage inflammatory protein-2-beta (MIP2b). CXCL3 controls migration and adhesion of monocytes and mediates it effects on its target cell by interacting with a cell surface chemokine receptor called CXCR2. The gene for CXCL3 is located on chromosome 4 in a cluster of other CXC chemokines.
NCBI/Uniprot data below describe general gene information for GRO g. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
11,342 Da
NCBI Official Full Name
C-X-C motif chemokine 3
NCBI Official Synonym Full Names
chemokine (C-X-C motif) ligand 3
NCBI Official Symbol
CXCL3  [Similar Products]
NCBI Official Synonym Symbols
GRO3; GROg; MIP2B; SCYB3; MIP-2b; CINC-2b
  [Similar Products]
NCBI Protein Information
C-X-C motif chemokine 3; GRO-gamma; GRO-gamma(1-73); GRO3 oncogene; MGSA gamma; MIP2-beta; growth-regulated protein gamma; macrophage inflammatory protein 2-beta; melanoma growth stimulatory activity gamma
UniProt Protein Name
C-X-C motif chemokine 3
UniProt Synonym Protein Names
GRO-gamma(1-73); Growth-regulated protein gamma; GRO-gamma; Macrophage inflammatory protein 2-beta; MIP2-beta
UniProt Gene Name
CXCL3  [Similar Products]
UniProt Synonym Gene Names
GRO3; GROG; SCYB3; GRO-gamma; MIP2-beta  [Similar Products]
UniProt Entry Name
CXCL3_HUMAN
NCBI Summary for GRO g
This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. [provided by RefSeq, Sep 2014]
UniProt Comments for GRO g
CXCL3: Ligand for CXCR2. Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: extracellular space; extracellular region

Molecular Function: chemokine activity; CXCR chemokine receptor binding

Biological Process: neutrophil chemotaxis; G-protein coupled receptor protein signaling pathway; immune response; response to lipopolysaccharide; positive regulation of leukocyte chemotaxis; inflammatory response; regulation of cell proliferation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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