BC053578
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
25,631 Da
NCBI Official Full Name
Homo sapiens glutathione S-transferase alpha 1, mRNA
NCBI Official Synonym Full Names
glutathione S-transferase alpha 1
NCBI Official Synonym Symbols
GST2; GTH1; GSTA1-1; GST-epsilon [Similar Products]
NCBI Protein Information
glutathione S-transferase A1
UniProt Protein Name
Glutathione S-transferase A1
UniProt Synonym Protein Names
GST HA subunit 1; GST class-alpha member 1; GST-epsilon; GSTA1-1; GTH1
UniProt Entry Name
GSTA1_HUMAN
NCBI Summary for GSTA1
This gene encodes a member of a family of enzymes that function to add glutathione to target electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress. This action is an important step in detoxification of these compounds. This subfamily of enzymes has a particular role in protecting cells from reactive oxygen species and the products of peroxidation. Polymorphisms in this gene influence the ability of individuals to metabolize different drugs. This gene is located in a cluster of similar genes and pseudogenes on chromosome 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
UniProt Comments for GSTA1
GSTA1: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Belongs to the GST superfamily. Alpha family.
Protein type: Xenobiotic Metabolism - metabolism by cytochrome P450; EC 2.5.1.18; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Other Amino Acids Metabolism - glutathione
Chromosomal Location of Human Ortholog: 6p12.1
Cellular Component: cytosol
Molecular Function: glutathione peroxidase activity; glutathione transferase activity
Biological Process: epithelial cell differentiation; glutathione metabolic process; linoleic acid metabolic process; metabolic process
Research Articles on GSTA1
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Pathways associated with GSTA1 cdna clone
Diseases associated with GSTA1 cdna clone
Organs/Tissues associated with GSTA1 cdna clone
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