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GSTT1 recombinant protein :: Glutathione S Transferase, T1-1 Human Recombinant Protein

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Catalog # MBS635557
Unit / Price
  0.1 mg  /  $610 +1 FREE 8GB USB
GSTT1 recombinant protein
Product Name

Glutathione S Transferase, T1-1 Human (GSTT1), Recombinant Protein

Popular Item
Also Known As

Glutathione S Transferase, T1-1, Recombinant Human (GST)

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 22; NC_000022.10 (24376135..24384284, complement). Location: 22q11.23
OMIM
600436
3D Structure
ModBase 3D Structure for P30711
Specificity
This purified product exhibits high enzymatic activity for CDNB, the synthetic substrate that is most commonly used for GST analyses. However, as is widely known for GST activity analysis using. CDNB as a substrate, low concentrations (high dilutions) of the enzyme result in lower activity values.
Purity/Purification
~95% (SDS-PAGE)
Specifications: >95%
Form/Format
Supplied as a liquid in 50mM Tris-HCl, pH 7.5, 50mM sodium chloride, 1mM DTT, 5mM EDTA and 50% glycerol.
Concentration
~1mg/ml
Specifications: 2.5mg/ml (lot specific)
Biological Activity
~30 Units/mg using spectrophotometric determination of 4- nitrobenzyl chloride conjugation with reduced glutathione (5mM) in 100mM NaPO4 (pH 6.5) at room temperature.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of GSTT1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for GSTT1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
NCBI Official Full Name
glutathione S-transferase theta-1
NCBI Official Synonym Full Names
glutathione S-transferase theta 1
NCBI Official Symbol
GSTT1  [Similar Products]
NCBI Protein Information
glutathione S-transferase theta-1; GST class-theta-1; glutathione transferase T1-1
UniProt Protein Name
Glutathione S-transferase theta-1
UniProt Synonym Protein Names
GST class-theta-1; Glutathione transferase T1-1
Protein Family
UniProt Gene Name
GSTT1  [Similar Products]
UniProt Entry Name
GSTT1_HUMAN
NCBI Summary for GSTT1
Glutathione S-transferase (GST) theta 1 (GSTT1) is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1 and GSTT2. The GSTT1 and GSTT2 share 55% amino acid sequence identity and both of them were claimed to have an important role in human carcinogenesis. The GSTT1 gene is located approximately 50kb away from the GSTT2 gene. The GSTT1 and GSTT2 genes have a similar structure, being composed of five exons with identical exon/intron boundaries. [provided by RefSeq, Jul 2008]
UniProt Comments for GSTT1
GSTT1: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2- epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4- nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide. Belongs to the GST superfamily. Theta family.

Protein type: Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; EC 2.5.1.18; Xenobiotic Metabolism - metabolism by cytochrome P450; Other Amino Acids Metabolism - glutathione

Chromosomal Location of Human Ortholog: 22q11.23

Cellular Component: cytosol

Molecular Function: glutathione transferase activity; glutathione peroxidase activity

Biological Process: glutathione metabolic process; xenobiotic metabolic process
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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