NP_001505.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
34,833 Da
NCBI Official Full Name
transcription initiation factor IIB
NCBI Official Synonym Full Names
general transcription factor IIB
NCBI Official Synonym Symbols
NCBI Protein Information
transcription initiation factor IIB; RNA polymerase II transcription factor IIB; S300-II; general transcription factor TFIIB
UniProt Protein Name
Transcription initiation factor IIB
UniProt Synonym Protein Names
General transcription factor TFIIB; S300-II
UniProt Synonym Gene Names
UniProt Entry Name
TF2B_HUMAN
NCBI Summary for GTF2B
This gene encodes the general transcription factor IIB, one of the ubiquitous factors required for transcription initiation by RNA polymerase II. The protein localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. Transcription factor IIB serves as a bridge between IID, the factor which initially recognizes the promoter sequence, and RNA polymerase II. [provided by RefSeq, Jul 2008]
UniProt Comments for GTF2B
GTF2B: General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II. Associates with TFIID-IIA (DA complex) to form TFIID-IIA- IIB (DAB-complex) which is then recognized by polymerase II. Interacts with the transcription elongation factor TCEA2. Interacts with HIV-1 Vpr. Interacts with GPBP1. Interacts with Epstein-Barr virus EBNA2. Belongs to the TFIIB family.
Protein type: Nuclear receptor co-regulator; Transcription factor; Acetyltransferase
Chromosomal Location of Human Ortholog: 1p22-p21
Cellular Component: nucleoplasm; nucleolus; nucleus
Molecular Function: protein binding; zinc ion binding; TATA-binding protein binding; thyroid hormone receptor binding; transcription factor binding
Biological Process: transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; viral reproduction; regulation of transcription, DNA-dependent; RNA elongation from RNA polymerase II promoter; gene expression
Research Articles on GTF2B
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Products associated with GTF2B recombinant protein
Pathways associated with GTF2B recombinant protein
Diseases associated with GTF2B recombinant protein
Organs/Tissues associated with GTF2B recombinant protein
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