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GUCY2D elisa kit :: Human guanylate cyclase 2D, membrane (retina-specific) ELISA Kit

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Catalog # MBS9331774
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GUCY2D elisa kit
Product Name

guanylate cyclase 2D, membrane (retina-specific) (GUCY2D), ELISA Kit

Popular Item
Full Product Name

Human Retinal guanylyl cyclase 1, GUCY2D ELISA Kit

Product Synonym Names
Human Retinal guanylyl cyclase 1 (GUCY2D) ELISA kit; CORD5; CORD6; CYGD; GUC1A4; GUC2D; LCA; LCA1; RCD2; RETGC-1; ROS-GC1; ROSGC; retGC; ; guanylate cyclase 2D; membrane (retina-specific)
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Request for Current Manual Insert
OMIM
gene 601777
3D Structure
ModBase 3D Structure for Q02846
Species Reactivity
Specificity
No significant cross-reactivity or interference between this analyte and analogues is observed.
Samples
Body fluids, tissue homogenates, secretions or feces samples
Assay Type
Quantitative Sandwich
Detection Range
3.12 ng/ml - 100 ng/ml
Sensitivity
1.0 ng/ml.
Intra-assay Precision
Intra-assay CV (%) is less than 15%
Inter-assay Precision
Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
Preparation and Storage
Store all reagents at 2-8 degree C
Product Note
Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
Other Notes
Small volumes of GUCY2D elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for GUCY2Dpurchase
MBS9331774 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the guanylate cyclase 2D, membrane (retina-specific) (GUCY2D) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing GUCY2D. The ELISA analytical biochemical technique of the MBS9331774 kit is based on GUCY2D antibody-GUCY2D antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect GUCY2D antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, GUCY2D. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
Related Product Information for
GUCY2D elisa kit
Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of GUCY2D (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
Sample Manual Insert of MBS9331774. Click to request current manual
NCBI/Uniprot data below describe general gene information for GUCY2D. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
120,059 Da
NCBI Official Full Name
retinal guanylyl cyclase 1
NCBI Official Synonym Full Names
guanylate cyclase 2D, membrane (retina-specific)
NCBI Official Symbol
GUCY2D  [Similar Products]
NCBI Official Synonym Symbols
LCA; CYGD; LCA1; RCD2; CORD5; CORD6; GUC2D; ROSGC; retGC; GUC1A4; RETGC-1; ROS-GC1
  [Similar Products]
NCBI Protein Information
retinal guanylyl cyclase 1; ROS-GC; cone rod dystrophy 6; guanylate cyclase 2D, retinal; rod outer segment membrane guanylate cyclase
UniProt Protein Name
Retinal guanylyl cyclase 1
UniProt Synonym Protein Names
Guanylate cyclase 2D, retinal; Rod outer segment membrane guanylate cyclase; ROS-GC
Protein Family
UniProt Gene Name
GUCY2D  [Similar Products]
UniProt Synonym Gene Names
CORD6; GUC1A4; GUC2D; RETGC; RETGC1; RETGC-1; ROS-GC  [Similar Products]
UniProt Entry Name
GUC2D_HUMAN
NCBI Summary for GUCY2D
This gene encodes a retina-specific guanylate cyclase, which is a member of the membrane guanylyl cyclase family. Like other membrane guanylyl cyclases, this enzyme has a hydrophobic amino-terminal signal sequence followed by a large extracellular domain, a single membrane spanning domain, a kinase homology domain, and a guanylyl cyclase catalytic domain. In contrast to other membrane guanylyl cyclases, this enzyme is not activated by natriuretic peptides. Mutations in this gene result in Leber congenital amaurosis and cone-rod dystrophy-6 diseases. [provided by RefSeq, Dec 2008]
UniProt Comments for GUCY2D
GUCY2D: Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction. Defects in GUCY2D are the cause of Leber congenital amaurosis type 1 (LCA1). LCA designates a clinically and genetically heterogeneous group of childhood retinal degenerations, generally inherited in an autosomal recessive manner. Affected infants have little or no retinal photoreceptor function as tested by electroretinography. LCA represents the most common genetic cause of congenital visual impairment in infants and children. Defects in GUCY2D are the cause of cone-rod dystrophy type 6 (CORD6). CORDs are inherited retinal dystrophies belonging to the group of pigmentary retinopathies. CORDs are characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Protein type: Protein kinase, dual-specificity (receptor); Protein kinase, RGC; Nucleotide Metabolism - purine; Lyase; Kinase, protein; Membrane protein, integral; EC 4.6.1.2; Receptor, misc.; Guanylyl cyclase; RGC group; RGC family

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: nuclear outer membrane; integral to plasma membrane

Molecular Function: guanylate cyclase activity; GTP binding; receptor activity; ATP binding; protein kinase activity

Biological Process: rhodopsin mediated signaling; cGMP biosynthetic process; phototransduction, visible light; regulation of rhodopsin mediated signaling; visual perception; receptor guanylyl cyclase signaling pathway; protein amino acid phosphorylation

Disease: Leber Congenital Amaurosis 1; Cone-rod Dystrophy 6
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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