NP_060424.9
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
142,883 Da
NCBI Official Full Name
calcium-dependent secretion activator 2 isoform a
NCBI Official Synonym Full Names
Ca++-dependent secretion activator 2
NCBI Protein Information
calcium-dependent secretion activator 2; CAPS-2; Ca2+-dependent activator protein for secretion 2; calcium-dependent activator protein for secretion 2
UniProt Protein Name
Calcium-dependent secretion activator 2
UniProt Synonym Protein Names
Calcium-dependent activator protein for secretion 2; CAPS-2
UniProt Synonym Gene Names
UniProt Entry Name
CAPS2_HUMAN
NCBI Summary for CADPS2
This gene encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium binding proteins that regulate the exocytosis of synaptic and dense-core vesicles in neurons and neuroendocrine cells. Mutations in this gene may contribute to autism susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]
UniProt Comments for CADPS2
CADPS2: Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca(2+)- dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles. 3 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 7q31.3
Cellular Component: presynaptic membrane; postsynaptic membrane; cytoplasmic vesicle membrane; cell junction
Molecular Function: metal ion binding; lipid binding
Biological Process: protein transport; cellular response to starvation; synaptic vesicle priming; positive regulation of exocytosis
Research Articles on CADPS2
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Diseases associated with CADPS2 elisa kit
Organs/Tissues associated with CADPS2 elisa kit
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