NP_783640.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
28,341 Da
NCBI Official Full Name
chromobox protein homolog 7
NCBI Official Synonym Full Names
chromobox homolog 7
NCBI Protein Information
chromobox protein homolog 7
UniProt Protein Name
Chromobox protein homolog 7
UniProt Entry Name
CBX7_HUMAN
UniProt Comments for CBX7
CBX7: Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.
Protein type: Transcription regulation
Chromosomal Location of Human Ortholog: 22q13.1
Cellular Component: nucleoplasm; heterochromatin; cytoplasm; nuclear chromatin; PcG protein complex; nucleus
Molecular Function: protein binding; single-stranded RNA binding; chromatin binding; methylated histone residue binding
Biological Process: transcription, DNA-dependent; sebaceous gland development; chromatin modification; negative regulation of transcription from RNA polymerase II promoter
Research Articles on CBX7
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Products associated with CBX7 elisa kit
Diseases associated with CBX7 elisa kit
Organs/Tissues associated with CBX7 elisa kit
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