NP_001013863.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
49,649 Da
NCBI Official Full Name
signal-transducing adaptor protein 2 isoform 2
NCBI Official Synonym Full Names
signal transducing adaptor family member 2
NCBI Official Synonym Symbols
NCBI Protein Information
signal-transducing adaptor protein 2; BRK substrate; brk kinase substrate; breast tumor kinase substrate; signal-transducing adaptor protein-2
UniProt Protein Name
Signal-transducing adaptor protein 2
UniProt Synonym Protein Names
Breast tumor kinase substrate; BRK substrate
UniProt Synonym Gene Names
UniProt Entry Name
STAP2_HUMAN
NCBI Summary for SDF-1alpha
This gene encodes the substrate of breast tumor kinase, an Src-type non-receptor tyrosine kinase. The encoded protein possesses domains and several tyrosine phosphorylation sites characteristic of adaptor proteins that mediate the interactions linking proteins involved in signal transduction pathways. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
UniProt Comments for SDF-1alpha
STAP2: a widely expressed proimflammatory adaptor protein that regulates immune and inflammatory responses. Binds and modulates a variety of molecules including Brk, CSFR, FCER1, and BCR-ABL. The interaction between STAP-2 and BCR-ABL appears to provide a growth advantage to BCR-ABL+ chronic myeloid leukemia cells. Suppression of STAP-2 expression in K562 CML cells suppressed tumor formation in mice. Enables intestinal proinflammatory responses in vivo: promotes macrophage recruitment in dextran sodium sulfate induced colitis, and promotes the ability of CXCL12-induced migration in macrophages. STAP-2 knockdown in T47D breast cancer cells induced a significant decrease of proliferation. Contains a pleckstrin homology, Src homology 2-like, and as well as a STAT3-binding domains. Two isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: cytoplasm; plasma membrane
Molecular Function: protein binding
Research Articles on SDF-1alpha
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Diseases associated with SDF-1alpha elisa kit
Organs/Tissues associated with SDF-1alpha elisa kit
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