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HAO2 sirna

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Catalog # MBS8237440
Unit / Price
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  15 nmol  /  $365 +1 FREE 8GB USB
  30 nmol  /  $515 +1 FREE 8GB USB
HAO2 sirna
Product Name

HAO2, siRNA

Full Product Name

HAO2 siRNA (Rat)

Product Synonym Names
HAO3; HAOX2; Hydroxyacid oxidase 2; HAOX2; S)-2-hydroxy-acid oxidase peroxisomal; Long chain alpha-hydroxy acid oxidase; Long-chain L-2-hydroxy acid oxidase
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q07523
Host
Synthetic
Species Reactivity
Rat
Specificity
HAO2 siRNA (Rat) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
Purity/Purification
> 97%
Form/Format
Lyophilized powder
Quality Control
Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
Directions for Use
We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
Components
We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of rat HAO2 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
Preparation and Storage
Shipped at 4 degree C. Store at -20 degree C for one year.
Negative Control
siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
Other Notes
Small volumes of HAO2 sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
HAO2 sirna
siRNA to inhibit HAO2 expression using RNA interference
Applications Tested/Suitable for HAO2 sirna
RNA Interference (RNAi)
NCBI/Uniprot data below describe general gene information for HAO2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
39,201 Da
NCBI Official Full Name
hydroxyacid oxidase 2
NCBI Official Synonym Full Names
hydroxyacid oxidase 2 (long chain)
NCBI Official Symbol
NCBI Official Synonym Symbols
NCBI Protein Information
hydroxyacid oxidase 2
UniProt Protein Name
Hydroxyacid oxidase 2
UniProt Synonym Protein Names
(S)-2-hydroxy-acid oxidase, peroxisomal; Long chain alpha-hydroxy acid oxidase; Long-chain L-2-hydroxy acid oxidase
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
Hao3; Haox2; HAOX2  [Similar Products]
UniProt Entry Name
HAOX2_RAT
NCBI Summary for HAO2
FMN-dependent alpha-hydroxy-oxidase enzyme that catalyzes the oxidation of L-alpha-hydroxy acids [RGD, Feb 2006]
UniProt Comments for HAO2
HAO2: Catalyzes the oxidation of L-alpha-hydroxy acids as well as, more slowly, that of L-alpha-amino acids. Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

Protein type: Oxidoreductase; EC 1.1.3.15; Carbohydrate Metabolism - glyoxylate and dicarboxylate

Cellular Component: mitochondrion; peroxisome

Molecular Function: FMN binding; (S)-2-hydroxy-acid oxidase activity; receptor binding

Biological Process: mandelate metabolic process; fatty acid oxidation; protein homooligomerization
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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