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HCAR2 recombinant protein :: Hydroxycarboxylic acid receptor 2 (HCAR2) Recombinant Protein

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Catalog # MBS7016521
Unit / Price
  0.01 mg  /  $995 +1 FREE 8GB USB
  0.05 mg  /  $1,500 +1 FREE 8GB USB
  0.1 mg  /  $2,430 +3 FREE 8GB USB
HCAR2 recombinant protein
Product Name

Hydroxycarboxylic acid receptor 2 (HCAR2), Recombinant Protein

Popular Item
Full Product Name

Recombinant Human Hydroxycarboxylic acid receptor 2 (HCAR2)

Product Gene Name

HCAR2 recombinant protein

[Similar Products]
Product Synonym Gene Name
GPR109A; HCA2; HM74A; NIACR1[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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Sequence Positions
1-363aa; full length protein
Sequence
MNRHHLQDHF LEIDKKNCCV FRDDFIVKVL PPVLGLEFIF GLLGNGLALW IFCFHLKSWK SSRIFLFNLA VADFLLIICL PFLMDNYVRR WDWKFGDIPC RLMLFMLAMN RQGSIIFLTV VAVDRYFRVV HPHHALNKIS NRTAAIISCL LWGITIGLTV HLLKKKMPIQ NGGANLCSSF SICHTFQWHE AMFLLEFFLP LGIILFCSAR IIWSLRQRQM DRHAKIKRAI TFIMVVAIVF VICFLPSVVV RIRIFWLLHT SGTQNCEVYR SVDLAFFITL SFTYMNSMLD PVVYYFSSPS FPNFFSTLIN RCLQRKMTGE PDNNRSTSVE LTGDPNKTRG APEALMANSG EPWSPSYLGP TSP
OMIM
609163
3D Structure
ModBase 3D Structure for Q8TDS4
Host
Cell Free Expression
Form/Format
Liquid containing glycerol
Species
Human
Storage Buffer
Tris-based buffer, 50% glycerol.
Tag Information
Tag type will be determined during the manufacturing process.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of HCAR2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Categories/Family for HCAR2 recombinant protein
Transmembrane Protein
Application Notes for HCAR2 recombinant protein
This is a recombinant transmembrane protein expressed in a cell-free expression system.
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NCBI/Uniprot data below describe general gene information for HCAR2. It may not necessarily be applicable to this product.
NCBI GI #
29171311
NCBI GeneID
338442
NCBI Accession #
NP_808219.1 [Other Products]
NCBI GenBank Nucleotide #
NM_177551.3 [Other Products]
UniProt Primary Accession #
Q8TDS4 [Other Products]
UniProt Secondary Accession #
A0PJL5; A7LGG3[Other Products]
UniProt Related Accession #
Q8TDS4[Other Products]
Molecular Weight
41,850 Da
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NCBI Official Full Name
hydroxycarboxylic acid receptor 2
NCBI Official Synonym Full Names
hydroxycarboxylic acid receptor 2
NCBI Official Symbol
HCAR2  [Similar Products]
NCBI Official Synonym Symbols
HCA2; HM74a; HM74b; PUMAG; NIACR1; Puma-g; GPR109A
  [Similar Products]
NCBI Protein Information
hydroxycarboxylic acid receptor 2
UniProt Protein Name
Hydroxycarboxylic acid receptor 2
UniProt Synonym Protein Names
G-protein coupled receptor 109A; G-protein coupled receptor HM74A; Niacin receptor 1; Nicotinic acid receptor
Protein Family
Hydroxycarboxylic acid receptor
UniProt Gene Name
HCAR2  [Similar Products]
UniProt Synonym Gene Names
GPR109A; HCA2; HM74A; NIACR1  [Similar Products]
UniProt Entry Name
HCAR2_HUMAN
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UniProt Comments for HCAR2
GPR109A: Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5- methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 12q24.31

Cellular Component: cell junction; integral to membrane; plasma membrane

Biological Process: G-protein coupled receptor protein signaling pathway; negative regulation of lipid catabolic process; neutrophil apoptosis; positive regulation of neutrophil apoptosis
Research Articles on HCAR2
1. These results suggest that the PKC pathway and PDGFR/EGFR transactivation pathway play important roles in HCA2-mediated Akt activation.
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Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with HCAR2 recombinant protein
 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Hydroxycarboxylic Acid-binding Receptors Pathway antibodies  Hydroxycarboxylic Acid-binding Receptors Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram
 CAMP Signaling Pathway antibodies  CAMP Signaling Pathway Diagram
 CAMP Signaling Pathway antibodies  CAMP Signaling Pathway Diagram
Diseases associated with HCAR2 recombinant protein
 Disease Name  Pubmed Publications
 Flushing Antibodies  >36 publications with HCAR2 and Flushing
 Cardiovascular Diseases Antibodies  >22 publications with HCAR2 and Cardiovascular Diseases
 Atherosclerosis Antibodies  >21 publications with HCAR2 and Atherosclerosis
 Inflammation Antibodies  >21 publications with HCAR2 and Inflammation
 Dyslipidemias Antibodies  >10 publications with HCAR2 and Dyslipidemias
 Arteriosclerosis Antibodies  >9 publications with HCAR2 and Arteriosclerosis
 Disease Models, Animal Antibodies  >9 publications with HCAR2 and Disease Models, Animal
 Necrosis Antibodies  >6 publications with HCAR2 and Necrosis
 Lung Diseases Antibodies  >4 publications with HCAR2 and Lung Diseases
 Insulin Resistance Antibodies  >4 publications with HCAR2 and Insulin Resistance
Organs/Tissues associated with HCAR2 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >36 publications with HCAR2 and Blood
 Skin Antibodies  >20 publications with HCAR2 and Skin
 Adipose Tissue Antibodies  >13 publications with HCAR2 and Adipose Tissue
 Lung Antibodies  >12 publications with HCAR2 and Lung
 Liver Antibodies  >10 publications with HCAR2 and Liver
 Brain Antibodies  >9 publications with HCAR2 and Brain
 Intestine Antibodies  >7 publications with HCAR2 and Intestine
 Eye Antibodies  >5 publications with HCAR2 and Eye
 Spleen Antibodies  >3 publications with HCAR2 and Spleen
 Muscle Antibodies  >1 publications with HCAR2 and Muscle
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