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HGF cdna clone

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Catalog # MBS1276192
Unit / Price
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  0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
HGF cdna clone
Product Name

HGF, cDNA Clone

Popular Item
Full Product Name

HGF cDNA Clone

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgtgggtga ccaaactcct gccagccctg ctgctgcagc atgtcctcct gcatctcctc ctgctcccca tcgccatccc ctatgcagag ggacaaagga aaagaagaaa tacaattcat gaattcaaga aatcagcaaa gactacccta atcaaaatag atccagcact gaagataaaa accaaaaaag tgaatactgc agaccaatgt gctaatagat gtactaggaa taaaggactt ccattcactt gcaaggcttt tgtttttgat aaagcaagaa aacaatgcct ctggttcccc ttcaatagca tgtcaagtgg agtgaaaaaa gaatttggcc atgaatttga cctctatgaa aacaaagact acattagaaa ctgcatcatt ggtaaaggac gcagctacaa gggaacagta tctatcacta agagtggcat caaatgtcag ccctggagtt ccatgatacc acacgaacac agctttttgc cttcgagcta tcggggtaaa gacctacagg aaaactactg tcgaaatcct cgaggggaag aagggggacc ctggtgtttc acaagcaatc cagaggtacg ctacgaagtc tgtgacattc ctcagtgttc agaaggtaaa taa
OMIM
142409
Vector
pENTR223.1
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of HGF cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for HGF. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
24,116 Da
NCBI Official Full Name
Homo sapiens hepatocyte growth factor (hepapoietin A; scatter factor), mRNA
NCBI Official Synonym Full Names
hepatocyte growth factor
NCBI Official Symbol
NCBI Official Synonym Symbols
SF; HGFB; HPTA; F-TCF; DFNB39
  [Similar Products]
NCBI Protein Information
hepatocyte growth factor
UniProt Protein Name
Hepatocyte growth factor
UniProt Synonym Protein Names
Hepatopoietin-A; Scatter factor; SF
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
HPTA; SF  [Similar Products]
UniProt Entry Name
HGF_HUMAN
NCBI Summary for HGF
This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss. [provided by RefSeq, Nov 2015]
UniProt Comments for HGF
HGF: HGF is a potent mitogen for mature parenchymal hepatocyte cells, seems to be an hepatotrophic factor, and acts as growth factor for a broad spectrum of tissues and cell types. It has no detectable protease activity. Activating ligand for the receptor tyrosine kinase MET by binding and promoting its dimerization. Defects in HGF are the cause of deafness autosomal recessive type 39 (DFNB39). A form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Belongs to the peptidase S1 family. Plasminogen subfamily. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Cell development/differentiation; Hormone

Chromosomal Location of Human Ortholog: 7q21.1

Cellular Component: extracellular region; extracellular space; membrane

Molecular Function: chemoattractant activity; protein binding

Biological Process: epithelial to mesenchymal transition; hepatocyte growth factor receptor signaling pathway; negative regulation of caspase activity; platelet degranulation; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphoinositide 3-kinase cascade

Disease: Deafness, Autosomal Recessive 39
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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