NP_058564.2
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
73,044 Da
NCBI Official Full Name
hypoxia-inducible factor 3-alpha isoform 2
NCBI Official Synonym Full Names
hypoxia inducible factor 3, alpha subunit
NCBI Protein Information
hypoxia-inducible factor 3-alpha; HIF3-alpha; HIF-3-alpha; HIF3-alpha-1; member of PAS protein 7; neonatal and embryonic PAS; inhibitory PAS domain protein; hypoxia inducible factor three alpha; basic-helix-loop-helix-PAS protein MOP7
UniProt Protein Name
Hypoxia-inducible factor 3-alpha
UniProt Synonym Protein Names
Basic-helix-loop-helix-PAS protein MOP7; HIF3-alpha-1; Inhibitory PAS domain protein; IPAS; Member of PAS protein 7
UniProt Synonym Gene Names
UniProt Entry Name
HIF3A_MOUSE
UniProt Comments for HIF3A
HIF3A: Involved in adaptive response to hypoxia. Suppresses hypoxia-inducible expression of HIF1A and EPAS1. Binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters. The complex HIF3A-ARNT activates the transcription of reporter genes driven by HRE. Isoform 4 has a dominant-negative function of inactivating HIF1A-mediated transcription. Isoform 4 attenuates the binding of HIF1A to hypoxia-responsive elements (HRE), thus inhibiting HRE-driven transcription. Hypoxia induces down-regulation of isoform 4, leading to activation of HIF1A in hypoxia. Conversely, upon restoring normoxia, the expression of isoform 4 increases and thereby secure an inhibition of HIF1A activity. Isoform 4 may be a negative regulator of hypoxia-inducible gene expression in the kidney and may be involved in renal tumorigenesis. Functions as an inhibitor of angiogenesis in the cornea. 7 isoforms of the human protein are produced by alternative splicing.
Protein type: Tumor suppressor; Transcription factor
Cellular Component: mitochondrion; cytoplasm; nuclear speck; nucleus
Molecular Function: protein dimerization activity; protein binding; signal transducer activity; DNA binding; transcription coactivator activity; transcription corepressor activity; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; transcription, DNA-dependent; response to hypoxia; positive regulation of transcription from RNA polymerase II promoter; signal transduction
Research Articles on HIF3A
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Diseases associated with HIF3A elisa kit
Organs/Tissues associated with HIF3A elisa kit
|