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anti-HIST1H2AI antibody :: Histone H2A Antibody

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Catalog # MBS852710
Unit / Price
  0.1 mg  /  $215 +1 FREE 8GB USB
Immunohistochemistry (IHC)
Product Name

Histone H2A (HIST1H2AI), Antibody

Popular Item
Also Known As

Histone H2A (Phospho-Thr121) Antibody

Product Synonym Names
H2A.1b; H2A/c; H2A/d; H2A/i; H2A/n; H2A/p; H2A1; H2AC; H2AFC; H2AFD ANDHIST1H2AL; H2AFI; H2AFN ANDHIST1H2AG; H2AFP; HIST1H2AI; HIST1H2AJ; HIST1H2AM; Histone H2A.c/d/i/n/p
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
130
OMIM
602787
3D Structure
ModBase 3D Structure for P0C0S8
Species Reactivity
Human, Mouse, Rat
Specificity
Histone H2A (Phospho-Thr121) antibody detects endogenous levels of Histone H2A only when phosphorylated at threonine 121.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
The antiserum was produced against synthesized phosphopeptide derived from human Histone H2A around the phosphorylation site of threonine 121 (K-K-TP-E-S).
All Sites
Human: Thr121
Mouse: Thr121
Rat: Thr121
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-HIST1H2AI antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-HIST1H2AI antibody
Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-HIST1H2AI antibody
IHC: 1:50-1:100
ELISA: 1:1000

Immunohistochemistry (IHC) of anti-HIST1H2AI antibody
P-peptide-+ Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using Histone H2A (Phospho-Thr121) antibody.
anti-HIST1H2AI antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for HIST1H2AI. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
14,091 Da[Similar Products]
NCBI Official Full Name
histone H2A type 1
NCBI Official Synonym Full Names
histone cluster 1 H2A family member i
NCBI Official Symbol
HIST1H2AI  [Similar Products]
NCBI Official Synonym Symbols
H2A/c; H2AFC
  [Similar Products]
NCBI Protein Information
histone H2A type 1
UniProt Protein Name
Histone H2A type 1
UniProt Synonym Protein Names
Histone H2A/ptl
Protein Family
UniProt Gene Name
HIST1H2AG  [Similar Products]
UniProt Synonym Gene Names
H2AFP; H2A.1  [Similar Products]
NCBI Summary for HIST1H2AI
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
UniProt Comments for HIST1H2AI
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Product References and Citations for anti-HIST1H2AI antibody
Albig W., Hum. Genet. 101:284-294(1997). Albig W., Biol. Chem. 380:7-18(1999). Dobner T., DNA Seq. 1:409-413(1991).

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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