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HLCS recombinant protein :: Biotin--protein ligase (HLCS) Recombinant Protein

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Catalog # MBS964962
Unit / Price
Scan QR to view Datasheet
  0.05 mg (E-Coli)  /  $1,160 +1 FREE 8GB USB
  0.05 mg (Yeast)  /  $1,165 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $1,405 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $1,565 +1 FREE 8GB USB
  0.2 mg (Yeast)  /  $1,590 +1 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,645 +2 FREE 8GB USB
  0.5 mg (E-Coli)  /  $1,725 +2 FREE 8GB USB
  0.5 mg (Yeast)  /  $1,800 +2 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $2,030 +2 FREE 8GB USB
  1 mg (E-Coli)  /  $2,600 +3 FREE 8GB USB
  0.5 mg (Baculovirus)  /  $2,605 +3 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $2,625 +3 FREE 8GB USB
  1 mg (Yeast)  /  $2,840 +3 FREE 8GB USB
  1 mg (Baculovirus)  /  $4,025 +5 FREE 8GB USB
HLCS recombinant protein
Product Name

Biotin--protein ligase (HLCS), Recombinant Protein

Full Product Name

Recombinant Human Biotin--protein ligase (HLCS)

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-726aa, Full length protein
Sequence
MEDRLHMDNG LVPQKIVSVH LQDSTLKEVK DQVSNKQAQI LEPKPEPSLE IKPEQDGMEH VGRDDPKALG EEPKQRRGSA SGSEPAGDSD RGGGPVEHYH LHLSSCHECL ELENSTIESV KFASAENIPD LPYDYSSSLE SVADETSPER EGRRVNLTGK APNILLYVGS DSQEALGRFH EVRSVLADCV DIDSYILYHL LEDSALRDPW TDNCLLLVIA TRESIPEDLY QKFMAYLSQG GKVLGLSSSF TFGGFQVTSK GALHKTVQNL VFSKADQSEV KLSVLSSGCR YQEGPVRLSP GRLQGHLENE DKDRMIVHVP FGTRGGEAVL CQVHLELPPS SNIVQTPEDF NLLKSSNFRR YEVLREILTT LGLSCDMKQV PALTPLYLLS AAEEIRDPLM QWLGKHVDSE GEIKSGQLSL RFVSSYVSEV EITPSCIPVV TNMEAFSSEH FNLEIYRQNL QTKQLGKVIL FAEVTPTTMR LLDGLMFQTP QEMGLIVIAA RQTEGKGRGG NVWLSPVGCA LSTLLISIPL RSQLGQRIPF VQHLMSVAVV EAVRSIPEYQ DINLRVKWPN DIYYSDLMKI GGVLVNSTLM GETFYILIGC GFNVTNSNPT ICINDLITEY NKQHKAELKP LRADYLIARV VTVLEKLIKE FQDKGPNSVL PLYYRYWVHS GQQVHLGSAE GPKVSIVGLD DSGFLQVHQE GGEVVTVHPD GNSFDMLRNL ILPKRR
OMIM
253270
3D Structure
ModBase 3D Structure for P50747
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Human
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of HLCS recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for HLCS. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
80,760 Da
NCBI Official Full Name
biotin--protein ligase isoform 1
NCBI Official Synonym Full Names
holocarboxylase synthetase
NCBI Official Symbol
NCBI Official Synonym Symbols
NCBI Protein Information
biotin--protein ligase
UniProt Protein Name
Biotin--protein ligase
UniProt Synonym Protein Names
Biotin apo-protein ligaseIncluding the following 4 domains:Biotin--[methylmalonyl-CoA-carboxytransferase] ligase (EC:6.3.4.9)Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase (EC:6.3.4.10)Alternative name(s):Holocarboxylase synthetase; HCS
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
NCBI Summary for HLCS
This gene encodes an enzyme that catalyzes the binding of biotin to carboxylases and histones. The protein plays an important role in gluconeogenesis, fatty acid synthesis and branched chain amino acid catabolism. Defects in this gene are the cause of holocarboxylase synthetase deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Jun 2011]
UniProt Comments for HLCS
Post-translational modification of specific protein by attachment of biotin. Acts on various carboxylases such as acetyl-CoA-carboxylase, pyruvate carboxylase, propionyl CoA carboxylase, and 3-methylcrotonyl CoA carboxylase.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with HLCS recombinant protein
 Reference Product  PubMed Publications
 BTD recombinant protein  >1 publications with HLCS and BTD
Organs/Tissues associated with HLCS recombinant protein
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