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HMGA2 elisa kit :: Human High mobility group protein HMGI-C (HMGA2) ELISA Kit

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Catalog # MBS9329886
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HMGA2 elisa kit
Product Name

High mobility group protein HMGI-C (HMGA2), ELISA Kit

Popular Item
Full Product Name

Human High mobility group protein HMGI-C (HMGA2) ELISA Kit

Product Synonym Names
high mobility group AT-hook 2; BABL; HMGI-C; HMGIC; LIPO; STQTL9; High-mobility group protein HMGI-C|high-mobility group (nonhistone chromosomal) protein isoform I-C
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Request for Current Manual Insert
Chromosome Location
Chromosome: 12; NC_000012.11 (66218240..66360071). Location: 12q15
OMIM
150699
3D Structure
ModBase 3D Structure for P52926
Species Reactivity
Preparation and Storage
Store all reagents at 2-8 degree C
Product Note
Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
Other Notes
Small volumes of HMGA2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for HMGA2purchase
MBS9329886 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the High mobility group protein HMGI-C (HMGA2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing HMGA2. The ELISA analytical biochemical technique of the MBS9329886 kit is based on HMGA2 antibody-HMGA2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect HMGA2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, HMGA2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
Sample Manual Insert of MBS9329886. Click to request current manual
NCBI/Uniprot data below describe general gene information for HMGA2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
11,832 Da
NCBI Official Full Name
high mobility group protein HMGI-C isoform a
NCBI Official Synonym Full Names
high mobility group AT-hook 2
NCBI Official Symbol
HMGA2  [Similar Products]
NCBI Official Synonym Symbols
BABL; LIPO; HMGIC; HMGI-C; STQTL9
  [Similar Products]
NCBI Protein Information
high mobility group protein HMGI-C; High-mobility group protein HMGI-C; high mobility group AT-hook protein 2; high-mobility group (nonhistone chromosomal) protein isoform I-C
UniProt Protein Name
High mobility group protein HMGI-C
UniProt Synonym Protein Names
High mobility group AT-hook protein 2
UniProt Gene Name
HMGA2  [Similar Products]
UniProt Synonym Gene Names
HMGIC  [Similar Products]
UniProt Entry Name
HMGA2_HUMAN
NCBI Summary for HMGA2
This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
UniProt Comments for HMGA2
HMGA2: Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Interacts with E4F1. Interacts with NEK2. Belongs to the HMGA family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Oncoprotein; DNA-binding

Chromosomal Location of Human Ortholog: 12q15

Cellular Component: nucleoplasm; nuclear chromosome; nucleus

Molecular Function: protein binding; nucleosomal DNA binding; DNA-(apurinic or apyrimidinic site) lyase activity; DNA binding; AT DNA binding; DNA-dependent protein kinase activity; 5'-deoxyribose-5-phosphate lyase activity; SMAD binding; transcription factor binding; DNA bending activity

Biological Process: fat cell differentiation; establishment and/or maintenance of chromatin architecture; positive regulation of apoptosis; multicellular organismal development; positive regulation of transcription, DNA-dependent; mesodermal cell differentiation; negative regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; base-excision repair; regulation of growth; chondrocyte differentiation; mitosis; negative regulation of retroviral genome replication; transcription, DNA-dependent; response to virus; heterochromatin formation; DNA damage response, detection of DNA damage; stem cell differentiation; DNA catabolic process, endonucleolytic; negative regulation of DNA binding; chromosome condensation; mesenchymal cell differentiation; cell division; mitotic cell cycle G2/M transition DNA damage checkpoint; chromosome breakage; epithelial to mesenchymal transition; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis

Disease: Leiomyoma, Uterine
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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