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HMGB2 cdna clone

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Catalog # MBS1269635
Unit / Price
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  0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
HMGB2 cdna clone
Product Name

HMGB2, cDNA Clone

Popular Item
Full Product Name

HMGB2 cDNA Clone

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgggtaaag gagaccccaa caagccgcgg ggcaaaatgt cctcgtacgc cttcttcgtg cagacctgcc gggaagagca caagaagaaa cacccggact cttccgtcaa tttcgcggaa ttctccaaga agtgttcgga gagatggaag accatgtctg caaaggagaa gtcgaagttt gaagatatgg caaaaagtga caaagctcgc tatgacaggg agatgaaaaa ttacgttcct cccaaaggtg ataagaaggg gaagaaaaag gaccccaatg ctcctaaaag gccaccatct gccttcttcc tgttttgctc tgaacatcgc ccaaagatca aaagtgaaca ccctggccta tccattgggg atactgcaaa gaaattgggt gaaatgtggt ctgagcagtc agccaaagat aaacaaccat atgaacagaa agcagctaag ctaaaggaga aatatgaaaa ggatattgct gcatatcgtg ccaagggcaa aagtgaagca ggaaagaagg gccctggcag gccaacaggc tcaaagaaga agaacgaacc agaagatgag gaggaggagg aggaataa
OMIM
163906
Vector
pENTR223.1
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of HMGB2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for HMGB2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
24,034 Da
NCBI Official Full Name
Homo sapiens high-mobility group box 2, mRNA
NCBI Official Synonym Full Names
high mobility group box 2
NCBI Official Symbol
HMGB2  [Similar Products]
NCBI Official Synonym Symbols
NCBI Protein Information
high mobility group protein B2
UniProt Protein Name
High mobility group protein B2
UniProt Synonym Protein Names
High mobility group protein 2; HMG-2
UniProt Gene Name
HMGB2  [Similar Products]
UniProt Synonym Gene Names
HMG2; HMG-2  [Similar Products]
UniProt Entry Name
HMGB2_HUMAN
NCBI Summary for HMGB2
This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. [provided by RefSeq, Jul 2008]
UniProt Comments for HMGB2
HMGB2: DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Belongs to the HMGB family.

Protein type: Nuclear receptor co-regulator; DNA-binding

Chromosomal Location of Human Ortholog: 4q31

Cellular Component: cell; condensed chromosome; cytoplasm; extracellular space; nuclear chromatin; nucleolus; nucleoplasm; nucleus; perinuclear region of cytoplasm; protein complex

Molecular Function: chemoattractant activity; damaged DNA binding; DNA bending activity; DNA binding; double-stranded DNA binding; drug binding; four-way junction DNA binding; protein binding; RAGE receptor binding; single-stranded DNA binding; transcription factor activity; transcription factor binding

Biological Process: defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; DNA fragmentation during apoptosis; DNA geometric change; DNA ligation during DNA repair; DNA topological change; inflammatory response to antigenic stimulus; negative regulation of transcription, DNA-dependent; positive regulation of DNA binding; positive regulation of endothelial cell proliferation; positive regulation of erythrocyte differentiation; positive regulation of megakaryocyte differentiation; positive regulation of nuclease activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of neurogenesis; regulation of transcription from RNA polymerase II promoter; response to drug; response to lipopolysaccharide; V(D)J recombination
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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