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HMGCS1 recombinant protein :: 3-Hydroxy-3-Methylglutaryl-CoA Synthase 1 Recombinant Protein

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Catalog # MBS140921
Unit / Price
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  0.002 mg  /  $140 +1 FREE 8GB USB
  0.01 mg  /  $205 +1 FREE 8GB USB
  0.1 mg  /  $1,220 +1 FREE 8GB USB
HMGCS1 recombinant protein
Product Name

3-Hydroxy-3-Methylglutaryl-CoA Synthase 1 (HMGCS1), Recombinant Protein

Full Product Name

Recombinant Human 3-Hydroxy-3-Methylglutaryl-CoA Synthase 1

Product Synonym Names
HMGCS1 Human; 3-Hydroxy-3-Methylglutaryl-CoA Synthase 1 Human Recombinant; 3-Hydroxy-3-Methylglutaryl-CoA Synthase 1 (Soluble); 3-Hydroxy-3-Methylglutaryl-Coenzyme A Synthase 1 (Soluble); 3-Hydroxy-3-Methylglutaryl Coenzyme A (HMG-CoA) Synthase; EC 2.3.3.10; HMGCS; Hydroxymethylglutaryl-CoA Synthase; Cytoplasmic; 3-Hydroxy-3-Methylglutaryl Coenzyme A Synthase; HMG-CoA Synthase
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MGSSHHH HHH SSGLVPRGSH MGSMPG SLPL NAEACWPKDV GIVALEIYFP SQYVDQAELE KYDGVDAGKY TIGLGQAKMG FCTDREDINS LCMTVVQNLM ERNNLSYDCI GRLEVGTETI IDKSKSVKTN LMQLFEESGN TDIEGIDTTN ACYGGTAAVF NAVNWIESSS WDGRYALVVA GDIAVYATGN ARPTGGVGAV ALLIGPNAPL IFERGLRGTH MQHAYDFYKP DMLSEYPIVD GKLSIQCYLS ALDRCYSVYC KKIHAQWQKE GNDKDFTLND FGFMIFHSPY CKLVQKSLAR MLLNDFLNDQ NRDKNSIYSG LEAFGDVKLE DTYFDRDVEK AFMKASSELF SQKTKASLLV SNQNGNMYTS SVYGSLASVL AQYSPQQLAG KRIGVFSYGS GLAATLYSLK VTQDATPGSA LDKITASLCD LKSRLDSRTG VAPDVFAENM KLREDTHHLV NYIPQGSIDS LFEGTWYLVR VDEKHRRTYA RRPTPNDDTL DEGVGLVHSN IATEHIPSPA KKVPRLPATA AEPEAAVISN GEH
OMIM
142940
3D Structure
ModBase 3D Structure for Q01581
Host
E Coli
Purity/Purification
Greater than 80.0% as determined by SDS-PAGE.
Form/Format
HMGCS1 protein solution (0.5mg/ml) containing Phosphate buffered saline (pH7.4), 10% glycerol and 1mM DTT.
Sterile Filtered clear solution.
Other Notes
Small volumes of HMGCS1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
HMGCS1 recombinant protein
Introduction: 3-Hydroxy-3-Methylglutaryl-CoA Synthase 1, also known as HMGCS1 is a member of the Belongs to the HMG-CoA synthase family. HMGCS1 condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.

Description: HMGCS1 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 543 amino acids (1-520 a.a) and having a molecular mass of 59.7kDa.HMGCS1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Categories/Family for HMGCS1 recombinant protein
NCBI/Uniprot data below describe general gene information for HMGCS1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
57,294 Da
NCBI Official Full Name
hydroxymethylglutaryl-CoA synthase, cytoplasmic
NCBI Official Synonym Full Names
3-hydroxy-3-methylglutaryl-CoA synthase 1
NCBI Official Symbol
HMGCS1  [Similar Products]
NCBI Official Synonym Symbols
HMGCS
  [Similar Products]
NCBI Protein Information
hydroxymethylglutaryl-CoA synthase, cytoplasmic
UniProt Protein Name
Hydroxymethylglutaryl-CoA synthase, cytoplasmic
UniProt Synonym Protein Names
3-hydroxy-3-methylglutaryl coenzyme A synthase
UniProt Gene Name
HMGCS1  [Similar Products]
UniProt Synonym Gene Names
HMGCS; HMG-CoA synthase  [Similar Products]
UniProt Entry Name
HMCS1_HUMAN
UniProt Comments for HMGCS1
HMGCS1: This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. Belongs to the HMG-CoA synthase family.

Protein type: Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - butanoate; EC 2.3.3.10; Lipid Metabolism - synthesis and degradation of ketone bodies; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; Transferase

Chromosomal Location of Human Ortholog: 5p14-p13

Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus; plasma membrane

Molecular Function: hydroxymethylglutaryl-CoA synthase activity

Biological Process: cholesterol biosynthetic process
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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