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HMGCS2 elisa kit :: Human 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial) ELISA Kit

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Catalog # MBS9323662
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HMGCS2 elisa kit
Product Name

3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial) (HMGCS2), ELISA Kit

Full Product Name

Human Hydroxymethylglutaryl-CoA synthase, mitochondrial, HMGCS2 ELISA Kit

Product Synonym Names
Human Hydroxymethylglutaryl-CoA synthase; mitochondrial (HMGCS2) ELISA kit; hydroxymethylglutaryl-CoA synthase 2; 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial)
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Request for Current Manual Insert
OMIM
gene 605911
3D Structure
ModBase 3D Structure for P54868
Species Reactivity
Preparation and Storage
Store all reagents at 2-8 degree C
Product Note
Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
Other Notes
Small volumes of HMGCS2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for HMGCS2purchase
MBS9323662 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial) (HMGCS2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing HMGCS2. The ELISA analytical biochemical technique of the MBS9323662 kit is based on HMGCS2 antibody-HMGCS2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect HMGCS2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, HMGCS2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
NCBI/Uniprot data below describe general gene information for HMGCS2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
56,635 Da
NCBI Official Full Name
hydroxymethylglutaryl-CoA synthase, mitochondrial isoform 2
NCBI Official Synonym Full Names
3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
NCBI Official Symbol
HMGCS2  [Similar Products]
NCBI Protein Information
hydroxymethylglutaryl-CoA synthase, mitochondrial; HMG-CoA synthase; 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial)
UniProt Protein Name
Hydroxymethylglutaryl-CoA synthase, mitochondrial
UniProt Synonym Protein Names
3-hydroxy-3-methylglutaryl coenzyme A synthase
UniProt Gene Name
HMGCS2  [Similar Products]
UniProt Synonym Gene Names
HMG-CoA synthase  [Similar Products]
UniProt Entry Name
HMCS2_HUMAN
NCBI Summary for HMGCS2
The protein encoded by this gene belongs to the HMG-CoA synthase family. It is a mitochondrial enzyme that catalyzes the first reaction of ketogenesis, a metabolic pathway that provides lipid-derived energy for various organs during times of carbohydrate deprivation, such as fasting. Mutations in this gene are associated with HMG-CoA synthase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
UniProt Comments for HMGCS2
HMGCS2: This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. Defects in HMGCS2 are the cause of HMG-CoA synthase deficiency (HMGCS deficiency); also known as deficiency of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase 2. Affected individuals present with severe hypoketotic hypoglycemia, mild hepatomegaly, or fatty liver, and a nondiagnostic pattern of urinary organic acids with increase of medium and short chain dicarboxylic acids. Belongs to the HMG-CoA synthase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial; EC 2.3.3.10; Lipid Metabolism - synthesis and degradation of ketone bodies; Carbohydrate Metabolism - butanoate; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Transferase; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis

Chromosomal Location of Human Ortholog: 1p13-p12

Cellular Component: mitochondrion; mitochondrial matrix; mitochondrial inner membrane

Molecular Function: hydroxymethylglutaryl-CoA synthase activity

Biological Process: isoprenoid biosynthetic process; ketone body biosynthetic process; ketone body metabolic process; cellular lipid metabolic process; cholesterol biosynthetic process

Disease: 3-hydroxy-3-methylglutaryl-coa Synthase 2 Deficiency
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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