NP_001019245.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
33,295 Da
NCBI Official Full Name
histamine N-methyltransferase isoform 2
NCBI Official Synonym Full Names
histamine N-methyltransferase
NCBI Protein Information
histamine N-methyltransferase
UniProt Protein Name
Histamine N-methyltransferase
UniProt Synonym Gene Names
UniProt Entry Name
HNMT_HUMAN
NCBI Summary for HNMT
In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for HNMT
HNMT: Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine. Belongs to the methyltransferase superfamily. HNMT family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Amino Acid Metabolism - histidine; EC 2.1.1.8; Methyltransferase
Chromosomal Location of Human Ortholog: 2q22.1
Cellular Component: nucleoplasm; neuron projection; cytoplasm
Molecular Function: histamine N-methyltransferase activity
Biological Process: methylation; hyperosmotic response; response to tumor cell; response to glucocorticoid stimulus; respiratory gaseous exchange; brain development; response to cocaine; response to amine stimulus
Disease: Asthma, Susceptibility To
Research Articles on HNMT
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Products associated with HNMT elisa kit
Pathways associated with HNMT elisa kit
Diseases associated with HNMT elisa kit
Organs/Tissues associated with HNMT elisa kit
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